系统性红斑狼疮血液系统受累的骨髓表现  

Characteristics of bone marrow examination in systemic lupus erythematosus patients with blood system damage

作　　者：邱茜[1] 李昊[1] 詹钟平[1] 梁柳琴[1] 

机构地区：[1]中山大学附属第一医院风湿免疫科,广州市510080

出　　处：《实用医学杂志》2017年第22期3719-3721,共3页The Journal of Practical Medicine

基　　金：广东省科技计划基金(编号:2016A020215051;2017A020215148)

摘　　要：目的探讨出现血液系统损害的系统性红斑狼疮患者骨髓检查结果的特点。方法对150例因狼疮血液系统损害而进行骨髓穿刺检查的患者资料进行回顾性分析。结果在150例患者中有68例患者出现骨髓检查异常,常见的骨髓检查异常分别为低增生性骨髓(26例,占38.2%)、噬血现象(17例,占25%)、纯红细胞再生障碍性贫血(6例,占8.8%),再生障碍性贫血(12例,17.6%)及巨核细胞数减少(7例,10.4%)。10例重度及极重度贫血(占重度及极重度贫血患者的90.9%)以及21例严重血小板减少的患者(占严重血小板减少患者的67.7%)出现了骨髓检查异常。结论系统性红斑狼疮患者出现骨髓异常并不少见,外周血检查发现严重贫血或是严重血小板减少时,需及早完善骨髓穿刺以及骨髓活检检查。Objective To investigate the characteristics of bone marrow examination in systemic lupus erythematosus （SLE） patients with blood system damage. Methods The data of 150 SLE patients with bone marrow puncture were analyzed retrospectively. Results Of the 150 patients, 68 patients had abnormalities in bone marrow examination. Common bone marrow abnormalities were low proliferative bone marrow （26 cases, 38.2% ） , hemophagocytic （17 cases, 25% ） , pure red blood cells aplastie anemia （6 cases, 8.8% ）, aplastie anemia （12 cases, 17.6% ） and decreased megakaryocyte count （7 cases, 10.4% ）. 10 cases of severe and severe anemia （90.9% of patients with severe and severe anemia ） and 21 patients with severe thromboeytopenia （67.7% of patients with severe thrombocytopenia） had abnormal bone marrow examination. Conclusions It is not uncommon for SLE patients to have abnormal bone marrow examination. When the peripheral blood test is found to be severe anemia or severe thrombocytopenia, bone marrow aspiration and bone marrow biopsy are needed.

关 键 词：系统性红斑狼疮 血液系统损害 骨髓检查 

分 类 号：R593.241[医药卫生—内科学]