羟考酮联合右美托咪啶对腹腔镜胃癌患者术后的镇痛效果  

Post-laparoscopic analgesic effect of oxycodone combined with dexmedetomidine for gastric cancer patients

作　　者：陈延云 于玲[1] 谭宏宇[1] 

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所麻醉科恶性肿瘤发病机制及转化研究教育部重点实验室,100142

出　　处：《实用医学杂志》2017年第22期3795-3798,共4页The Journal of Practical Medicine

摘　　要：目的探讨羟考酮联合右美托咪啶应用于腹腔镜胃癌患者术后的镇痛效果。方法本院外科2016年11月至2017年1月择期行腹腔镜胃癌手术的患者40例,美国麻醉医师协会(ASA)分级Ⅰ或Ⅱ级,采用随机数字表法分为2组:羟考酮组(O组,n=20)和羟考酮+右美托咪啶组(OD组,n=20)。术后采用患者视觉模拟疼痛评分(VAS)、镇痛泵按压次数、Ramsay评分及患者满意度等指标对两组患者开泵后2、5、8、11、24、48 h的镇痛效果进行评估,同时记录和观察两组患者的不良反应。结果两组患者开泵后2、5、8、11、24、48 h的镇痛效果比较发现OD组的VAS评分和按压次数均低于O组(P<0.05),两组Ramsay评分差异无统计学意义(P>0.05),OD组的满意度评分高于O组满意度评分(P<0.05)。两组患者术后均有头晕、恶心、呕吐等不良反应发生,差异无统计学意义(P>0.05)。结论羟考酮联合右美托咪啶对腹腔镜胃癌患者术后具有良好的镇痛作用。Objective To observe the post-laparoscopic analgesic effect of oxycodone combined with dexmedetomidine for gastric cancer patients. Methods A total of 40 gastric cancer patients who underwent laparoscopy during November 2016 and January 2017 and assessed with physical status Ⅰ or Ⅱ according to American Society of Anesthesiologists, were randomly divided into 2 groups： oxycodone group （group O, n = 20） and oxyeodone plus dexmedetomidine group （group OD, n = 20）. The anestheasic effects at the time points of hours 2, 5, 8, 11 and 24 after the operation were assessed by using visual analog pain score, times for pressing the pump, Ramsay score and patient＇ s satisfaction index of the two groups. At the same time, the adverse effects of two groups were recorded and observed. Results The analgesic effect after starting the pump at hours 2, 5, 8, 11, 24 and 25, the VAS scores and the pressure time in group OD were significantly lower than in group O （P 〈 0.05）, and the Ramsay scores were insignificantly different between the groups （P 〉 0.05 ）. In group OD, the patient＇s satisfaction level was significantly higher than in group O （P 〈 0.05 ）. Nausea, vomiting and dizziness occurred in both groups without significantly difference between the two groups. Conclusion Oxycodone combined with dexmedetomidine can provide satisfactory analgesia for gastric cancer patients receiving laparoscopic surgery.

关 键 词：羟考酮 右美托咪啶 镇痛 腹腔镜术后 

分 类 号：R614[医药卫生—麻醉学] R735.2[医药卫生—外科学]