糖耐量正常女性肥胖人群1h血糖与颈动脉内膜增厚的相关性研究  

Relationship between lh Post-Load Plasma Glucose Elevation and Carotid Intima-Media Thickness in Obese Women with Normal Glucose Tolerance

作　　者：陆强[1] 朱东林[1] 王锐[1] 郑岳[1] 贾晓娇[1] 刘悦[1] 王红[1] 

机构地区：[1]河北省秦皇岛市第一医院,河北秦皇岛066000

出　　处：《医学临床研究》2017年第11期2124-2127,共4页Journal of Clinical Research

基　　金：2014秦皇岛市科技研究与发展指导计划（201401A119）

摘　　要：[目的]探讨糖耐量正常的肥胖女性糖负荷1小时血糖（1hPG）与颈动脉内膜中层厚度（CIMT）的相关性。【方法】选取2014年5～12月在河北省秦皇岛市第一医院体检中心进行体检的186例女性，按体质量指数（BMI）将其分为正常组、超重组和肥胖组。所有研究对象行口服葡萄糖耐量试验，并测定CIMT。比较三组不同时间点血糖、胰岛素（INS）水平，分析CIMT的相关影响因素。【结果】肥胖组收缩压（SBP）、三酰甘油（TG）、CI—MT高于正常组，肥胖组胰岛素抵抗指数（HOMAIR）高于超重组，差异均具有统计学意义（均P〈0．05）。肥胖组血清1hPG、0hINS、1hINS水平显著高于正常组，0hINS、1hINS水平显著高于超重组，差异均具有统计学意义（均P〈0．05）。CIMT与BMI（r=0．316，P=0．001）、FPG（r=0．328，P〈0．001）、1hPG（r=0．263，P=0．005）均具有相关性（P〈0．05）。多元线性回归显示，1hPG、年龄、BMI与CIMT呈显著正相关（P〈0．05）。【结论】糖耐量正常的肥胖女性已存在1hPG、1hINs升高及胰岛素抵抗，1hPG是CIMT的独立危险N素。[Objective]To explore the relationship between lh post load plasma glucose （lhPG） elevation and carotid intima-media thickness （CIMT） in obese women with normal glucose tolerance （NGT）.[Methods]A total of 186 women who underwent physical examination in our hospital （May to December, 2014） were collected for the study. They were 18-57 years old with NGT. According to the body mass index （BMI）, all cases were divided into normal （ n=82）, overweight （ n=63） and obese （ n =41） groups. All subjects underwent an oral glucose tolerance test （OGTT） and CIMT. The levels of blood glucose and insulin （INS） were compared among the three groups. Furthermore, the correlation between lhPG and CIMT was analyzed. [Results] Systolic blood pressure （SBP）, triglyceride （TG） and CIMT in the obese group were higher than those in the normal group （ P〈0.05）. Insulin resistance index （HOMA IR） in the obese group was _higher than that in the overweight group （ P 〈 0.05）. Serum 1hPG, 0hINS and lhlNS levels in the obese group were significantly higher than those in the normal group, and serum 0hINS and lhINS levels were significantly higher than those in the overweight group. All differences were statistically significant （P %0.05）. Other parameters （0.5hPG, 1 hPG, 2hPG, 3bPG, 0. SHINS, 2hlNS and 3bINS） in the three groups were not statistically significant. CIMT was correlated with BMI （ r = 0.316,P〈0.001）, fasting pIasma glucose （FPG） （ r = 0.328, P 〈0.328）, and lhPG （ r = 0.263,P=0.005）, （all P〈0.05）. Multiple linear regression showed that lhPG, age and BMI had a significant positive correlation with CIMT （ P 〈0.05）. [Conclusion] Obese women with normal glucose tolerance have lhPG, lhINS and insulin resistance, lhPG is an independent risk factor for carotid intima-media thickening （CIMT）.

关 键 词：葡糖耐量试验 肥胖症 血糖 颈动脉疾病 危险因素 

分 类 号：R544.1[医药卫生—心血管疾病]