脂肪细胞膜相关蛋白的研究进展  

Progress of adipocyte plasma membrane associated protein

作　　者：黄婧婧 马宇航[1] 王育璠[1] 

机构地区：[1]上海交通大学附属第一人民医院内分泌代谢科,上海201620

出　　处：《上海交通大学学报（医学版）》2017年第11期1547-1550,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81600611);上海市浦江人才计划(15PJD032);上海市教育委员会高峰高原学科建设计划(20152231)~~

摘　　要：脂肪细胞膜相关蛋白(APMAP)是一种新型整合膜蛋白,在人体内多种组织器官中表达,能够促进前脂肪细胞向成熟脂肪细胞分化,从而维持脂肪细胞的正常生理代谢功能,并在脂肪细胞分化的过程中发挥着重要作用。目前,研究表明APMAP与人体内炎症反应的发生发展密切相关,与妊娠期糖尿病等多种疾病有关。该文对APMAP的结构和功能进行总结,综述近年来关于APMAP的研究进展。Adipocyte plasma membrane associated protein （APMAP） is a novel integral membrane protein, widely expressed in many organizations in humans. It promotes the differentiation of preadipocytes to mature adipocytes, so as to maintain normal physiological metabolism function in adipocytes, and plays a major role in adipocytes differentiation. Nowadays, some progress has been made in its role of inflammation and consequently in pathogenesis of gestational diabetes mellitus and other diseases. This paper gives a brief review about the structure and function of APMAP and sums up progress of the current studies.

关 键 词：脂肪细胞膜相关蛋白 脂肪细胞分化 结构 功能 

分 类 号：R589.2[医药卫生—内分泌]