阿司匹林对大鼠颅内动脉瘤形态和瘤壁结构的影响  

Effects of aspirin on morphology and wall structure of intracranial aneurysm in rats

作　　者：姚鹏飞[1] 程刚[1] 石鹏飞[1] 王洪运[1] 王向阳[1] 

机构地区：[1]兰州军区兰州总医院安宁分院神经外科,730070

出　　处：《国际脑血管病杂志》2017年第9期824-828,共5页International Journal of Cerebrovascular Diseases

基　　金：甘肃省科技计划项目（1506RJZA304）

摘　　要：目的探讨阿司匹林对血流动力学诱导的颅内动脉瘤形态和瘤壁结构的影响。方法26只SD大鼠随机分为对照组、模型组和阿司匹林组。结扎右侧颈总动脉及左侧颈外动脉、翼颚动脉，改变左侧颈内动脉血流动力学。诱导3个月后，获取经心脏灌注后的前交通动脉复合体，扫描电镜观察动脉瘤样结构并分级，病理学观察内弹力层和中膜平滑肌的变化。结果模型组和阿司匹林组均出现动脉瘤样重构，2组形态学分级差异无统计学意义（P＝0.054）。病理学检查显示，模型组和阿司匹林组瘤壁内弹力层出现皱褶或缺失，中膜平滑肌层变薄弱。模型组中膜变薄长度显著高于阿司匹林组[（173.50±17.62）μm对（153.50±12.04）μm；t＝2.964，P＝0.008]。结论阿司匹林可减缓颅内动脉瘤壁的病理重构，但不能完全抑制颅内动脉瘤生成。ObjectiveTo investigate the effects of aspirin on the morphology and wall structure of the intracranial aneurysm induced by hemodynamics.MethodsTwenty-six SD rats were randomly divided into three groups： a control group, a model group, and an aspirin group. The right common carotid artery, left external carotid artery, and pterygopalatine artery were ligated in order to change the hemodynamics of left internal carotid artery. After 3-month induction, the anterior communicating artery complex were harvested after heart perfusion. The aneurysm-like structure was observed using a scanning electron microscope and was graded. The changes of elastic layer and smooth muscle cells in the tunica media were detected by pathological examination.ResultsAneurysm-like remodeling was observed both in the model group and in the aspirin group, and there was no statistical differences in morphological grade between the 2 groups （P=0.054）. Pathological examination showed the folds or loss of the internal elastic lamina and thinned media smooth muscle layer both in the model group and in the aspirin group. The length of thinned media in the model group was significantly higher than that in the aspirin group （173.50±17.62 μm vs. 153.50±12.04 μm; t=2.964, P=0.008）. ConclusionsAspirin can slow down the pathological remodeling of intracranial aneurysm wall, but it cannot completely inhibit the formation of intracranial aneurysm.

关 键 词：颅内动脉瘤 阿司匹林 血流动力学 脑动脉 疾病模型 动物 大鼠 

分 类 号：R743[医药卫生—神经病学与精神病学]