IMP3恶性肿瘤的诊断及预后标志物  

IMP3,the Malignant Tumors' Diagnostic and Prognostic Marker

作　　者：王小娟 成洲[1] 王晓萍 贾晓宁 

机构地区：[1]青岛大学附属烟台毓璜顶医院口腔科,山东烟台264003

出　　处：《医学综述》2017年第23期4633-4637,共5页Medical Recapitulate

摘　　要：胰岛素样生长因子ⅡmRNA结合蛋白3(IMP3)是胰岛素样生长因子RNA结合蛋白家族的一员。其所含有的2个RNA识别基序和4个同源K-域使得RNA结合蛋白更加稳固并具特殊性。IMP3是一种被公认的癌胚蛋白,主要存在于发育的胚胎组织中,其表达与一些恶性肿瘤相关。IMP3特异性表达于晚期及发生转移的恶性肿瘤中,但在其相邻接的良性组织中并未发现。另外,体外研究显示IMP3能促进肿瘤细胞的增殖、黏附、侵袭。Insulin-like growth factor H mRNA binding protein 3 （ IMP3 ） is a member of RNA-binding proteins family. These proteins contain 2 RNA recognition motifs and 4 K-homology domains that allow them to bind RNAs strongly and specifically. IMP3 is an oneofetal protein involved in embryogenesis and its expression is associated with a number of malignant neoplasms. IMP3 is associated with aggressive and advanced cancers and is specifically expressed in malignant tumors but is not found in adjacent benign tissues. Moreover, in vitro studies have shown that IMP3 promotes tumor cell proliferation, adhesion, and invasion.

关 键 词：胰岛素样生长因子ⅡmRNA结合蛋白3 恶性肿瘤 诊断标志物 预后标志物 

分 类 号：R246.83[医药卫生—针灸推拿学]