益智仁-乌药醚提取物对肾阳虚多尿模型大鼠血环磷酸腺苷和醛固酮水平的影响  

Effect of the ether extract of the Yizhiren-Wuyao on Camp,ALD levels in polyuria model of Yang-deficiency rats

作　　者：朱叶[1] 谢毅强[1] 尹德辉[1] 

机构地区：[1]海南医学院第一附属医院,海南海口571199

出　　处：《中国老年学杂志》2017年第22期5498-5499,共2页Chinese Journal of Gerontology

基　　金：国家自然科学基金(81473618;81360586)

摘　　要：目的观察益智仁-乌药醚提取物对肾阳虚多尿模型大鼠的血环磷酸腺苷(c AMP)和醛固酮(ALD)水平的影响。方法应用腺嘌呤(250 mg/kg)造模,给予大鼠灌胃4 w,分别给予阳性对照药厄贝沙坦、益智仁-乌药醚提取物治疗4 w,观察益智仁-乌药醚提取物对大鼠c AMP和ALD的影响。结果与正常对照组比较,模型组大鼠血浆c AMP含量显著升高(P<0.01),血清ALD含量明显降低(P<0.01);益智仁-乌药醚提取物高剂量组血浆c AMP含量较模型组明显升高(P<0.05),血清ALD含量较模型组明显升高(P<0.05)。结论益智仁-乌药醚提取物能够提高肾阳虚多尿模型大鼠血浆c AMP和血清ALD水平。Objective To observe the influence of ether extract of the Yizhiren-Wuyao on the levels of cyclic adenosine monophosphate（ c AMP）,aldosterone（ ALD） in polyuria model of Yang-deficiency rats. Methods The model rats were induced by given adenine（ 250 mg/kg）. After irrigation for 4 w,the levels of c AMP and ALD in the four groups were measured. Results Compared with those of normal control group,the c AMP level was significantly elevated,the ALD level was significantly decreased in model group（ P〈0. 01）; the levels of c AMP and ALD in Yizhiren-Wuyao high-dose group were significantly higher compared with those of model group（ P〈0. 05）. Conclusions Extract of the Yizhiren-Wuyao could increase plasma c AMP and ALD levels in polyuria model of yang-deficiency rats.

关 键 词：肾阳虚多尿模型 益智仁 乌药 环磷酸腺苷(c AMP) 醛固酮(ALD) 

分 类 号：R287[医药卫生—中药学]