中国青海藏族Graves眼病与CTLA-4基因多态性的相关性  

Association of the gene polymorphism of cytotoxic T lymphocyte-associated antigen-4 with Graves ophthalmopathy in Qinghai Tibetans

作　　者：王淑琼[1] 姚勇利[1] 

机构地区：[1]青海省人民医院内分泌Ⅱ病区

出　　处：《中华内分泌代谢杂志》2017年第11期962-964,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：青海省科技厅课题项目（2014-ZJ-769）

摘　　要：为了探讨细胞毒性T淋巴细胞相关抗原4（cytotoxic T lymphocyte-associated antigen-4, CTLA-4）基因多态性与青海省藏族Graves眼病（Graves′ ophthalmopathy，GO）的相关性。本组选择了2013年6月至2016年11月在青海省人民医院确诊的藏族Graves病（GD）患者130例作为观察对象，将130例GD患者分为GO组（71例）和无眼病GD组（59例），采用限制性片段长度多态性聚合酶链反应（PCR-RFLP）方法，检测观察对象血清中CTLA-4基因外显子1＋49位A/G基因型及等位基因频率。CTLA-4基因外显子1＋49位A/G基因型（AA、AG、GG）频率在在GO组与无眼病GD组比较差异有统计学意义。To investigate the association of the gene polymorphism of cytotoxic T lymphocyte-associated antigen-4 （CTLA-4）with Graves′ ophthalmopathy（GO）in Qinghai Tibetans. 130 case of Graves′ disease（GD）were selected from June 2013 to November 2016 in The People′s Hospital of Qinghai Province. These patients were assigned into 2 groups, GO（n=71）and GD without GO（n=59）. The genotypes and alleles of CTLA-4 gene were detected by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）. Distribution of CTLA-4 exon 1（＋ 49A/G）genotype frequencies（AA, AG, and GG）was different between 2 groups.

关 键 词：格雷夫斯病 多态性 限制性片段长度多态性 

分 类 号：R581.1[医药卫生—内分泌]