住院药疹239例致敏药物分析  

Analysis of allergenic drugs in 239 inpatients with drug eruptions

作　　者：毛爱迪 孙仁山[1,2] 雷霞 吴津津[1,2] 黄显琼 

机构地区：[1]第三军医大学大坪医院皮肤科 [2]中华医学皮肤性病学分会药物不良反应研究中心,重庆400042

出　　处：《中国麻风皮肤病杂志》2017年第11期660-662,共3页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金(编号:81571569);2017年中华医学会;欧莱雅中国人健康皮肤研究项目(编号:S2017140916)

摘　　要：目的:明确239例药疹的主要致敏药物种类。方法:对本院皮肤科2007年5月至2017年4月就诊的239例药疹患者临床资料进行回顾性分析。结果:239例药疹患者中可确定致敏药物有105例(非重症药疹患者88例,重症药疹患者17例)。非重症药疹致敏药物主要为抗生素类32例(36.4%),解热镇痛药17例(19.3%)、中药16例(18.2%)。重症药疹主要致敏药物为抗生素类5例(29.4%),解热镇痛药3例(17.6%)、卡马西平类3例(17.6%)、抗痛风类药物3例(17.6%)。结论:本组患者药疹最常见的致敏药物为抗生素类。Objective： To analyze the causative drugs in 239 inpatients with drug eruptions. Methods： Data of inpatients suffered from drug eruptions from May 2007 to April 2017 in our department were analyzed retrospectively. Results： Out of 239 patients,the allergenic drugs in 105 patients were identified,including 88 patients with severe drug eruption and 17 patients with non-severe drug eruption. The allergenic drugs in the patients with non-severe drug eruptions mainly included antibiotics in 32 patients（ 36.4%）,antipyretic analgesics in 17（ 19.3%） and traditional Chinese medicine in 16（ 18.2%）. The allergenic drugs in the patients with severe drug eruptions mainly included antibiotics in 5 patients（ 29. 4%）,antipyretic analgesics in 3（ 17.6%） carbamazepine in 3（ 17.6%） and antigout drugs in 3（ 17.6%）. Conclusion： The most allergenic drugs are antibiotics in this study.

关 键 词：药疹 临床分析 潜伏期 回顾性分析 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]