急性百草枯中毒临床救治疗效分析  

Analysis of clinical effect of different methods of acuteparaquat- poisoned patients

作　　者：黄杨[1] 孙纪元[2] 尹文[1] 王玉同[1] 赵威[1] 瞿丽娟[1] 崔锐红[1] 孙应辉 

机构地区：[1]第四军医大学西京医院急诊科,西安710032 [2]第四军医大学药物研究所

出　　处：《中国急救复苏与灾害医学杂志》2017年第11期1035-1037,共3页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：陕西省自然科学基金资助项目（2016JM8144）;西京医院学科助推计划（XJZT15ZC08）

摘　　要：目的通过对急性PQ中毒治疗方法的分析探讨其疗效。方法将2013年1月-2015年12月第四军医大学西京医院收治的221例急性PQ口服中毒患者甲基强的松龙和环磷酰胺的治疗方案、是否行血液净化治疗的疗效进行对比分析。结果①服毒剂量〉5mL行血液净化治疗的急性PQ患者死亡率均低于未行血液净化治疗的中毒患者（P〈0．01）。②服毒剂量为5-50mL时，甲基强的松龙联合环磷酰胺治疗组的死亡率明显低于甲基强的松龙治疗组的死亡率（P〈0．05）。当服毒剂量为50-100mL时，甲基强的松龙治疗组的死亡率显著低于甲基强的松龙联合环磷酰胺治疗组的死亡率（P〈0．01）。当服毒剂量〉100mL时，两治疗组患者死亡率差异无统计学意义（P〉0．05）。结论急诊PQ中毒救治疗效与服毒剂量密切相关。Objective To evaluate the clinic efficacy by analyzing the different treatment methods of acute paraquat poisoning. Methods Clinical data of 221 paraquat-poisoned patients admitted into the emergency department Was recorded, and the therapies of Methylprednisolone and cyclophosphamide combined with blood purification were retrospectively analysis. Results ①When the toxic dose was larger than 5ml, the mortalities of paraquat-poisoned patients in the treatment of blood purification were significantly lower than the patients without the treatment of blood purification （P〈 0.01 ）. ②When the toxic dose was between 5 and 50mi, the mortalities of patients in the groups of methylprednisolone combined cyclophosphamide were obviously lower than than the patients in the groups of methylprednisolone （P〈 0.05）. When the toxic dose was between 50 and 100ml, the mortality of patients in the groups of methylprednisolone was markedly lower than the patients in the groups of methylprednisolone combined cyclophosphamide （P 〈 0.01 ）. When the toxic dose was larger than 100ml, there was no significant difference between the both groups（P〉 0.05）. Conclusion Different methods were alternatively chosen closely related to the toxic dose in the treatment of acute paraquat poisoning.

关 键 词：百草枯 中毒 治疗 

分 类 号：R595.4[医药卫生—内科学]