人副流感病毒3型包膜糖蛋白相互作用机制的研究进展  

Research progress in interaction mechanism of enveloped glycoproteins of human parainfluenza virus type 3

作　　者：姜晶晶 王志玉 

机构地区：[1]山东大学公共卫生学院病毒学研究室,济南250012

出　　处：《中华实验和临床病毒学杂志》2017年第5期466-471,共6页Chinese Journal of Experimental and Clinical Virology

基　　金：国家自然科学基金（81672011）

摘　　要：人副流感病毒（Human parainfluenza viruses,hPIVs）属于副粘病毒科的单股负链RNA病毒,也是引起呼吸道感染的主要病原体,其中hPIV3是引起六个月以下婴幼儿发生细支气管炎和肺炎的第二大病原体,仅次于呼吸道合胞病毒.本文主要介绍人副流感病毒3型的两种与毒力相关的表面糖蛋白、血凝素神经氨酸酶（HN）蛋白和融合蛋白（F）,根据国内外最新的研究进展,介绍其蛋白结构和生理学功能,尤其是在膜融合过程中HN与F的相互作用机制.Human parainfluenza viruses （hPIVs）,a series of single-stranded RNA viruses of Paramyxoviridae,are the main pathogen of respiratory tract infection.hPIV3 is the main cause of lower respiratory tract infection leading to bronchiolitis and pneumonias in young children under the age of six months,and it is the second major pathogen only next to respiratory syncytial virus （RSV）.In this paper,we mainly discuss two kinds of virulence-related surface glycoprotein of hPIV3：hemagglutinin-neuraminidase （HN） protein and fusion protein （F） by briefly introducing the protein structure and physiological functions of HN and F.According to the latest research progress,we focus on the models which have been postulated to explain how F and HN work in concert to bring about membrane fusion.

关 键 词：副流感病毒 血凝素神经氨酸酶蛋白 融合蛋白 作用机制 膜融合 

分 类 号：R373[医药卫生—病原生物学]