二甲双胍对多囊卵巢综合征不孕症患者的治疗及临床观察  

Clinical observation of metformin in treatment of infertile women with polycystic ovary syndrome

作　　者：潘利 黎会丽 刘洁 李睿 

机构地区：[1]陕西省咸阳市中心医院,陕西咸阳712000

出　　处：《中国妇幼健康研究》2017年第11期1415-1418,共4页Chinese Journal of Woman and Child Health Research

摘　　要：目的观察二甲双胍治疗多囊卵巢综合症不孕症患者的疗效,探讨其临床价值。方法选择陕西省咸阳市中心医院于2014年1月至2015年6月收治的多囊卵巢综合征不孕症患者100例作为研究对象,按照配对分组法分为对照组和观察组,每组50例,对照组给予口服达英-35治疗,观察组于对照组基础上联合应用二甲双胍治疗,两组均连续服药3个月,比较两组疗效。结果两组患者治疗前体质量指数、黄体生成素、睾酮水平比较均无统计学差异(t值分别为0.869、1.534、1.153,均P>0.05);治疗后观察组体质量指数、黄体生成素、睾酮水平均低于对照组,且两组治疗后水平均低于治疗前(t=7.889~25.876,均P<0.05)。两组患者治疗前、治疗后空腹血糖及2h血糖水平比较均无显著统计学差异(t值分别为0.665、0.905、0.766、0.665,均P>0.05);观察组治疗后空腹胰岛素及2h胰岛素水平均显著低于对照组,且均低于术前(t值分别为37.915,18.404,均P<0.05)。观察组治疗后排卵率及妊娠率分别为72.0%(36例)、42.0%(21例),均显著高于对照组52.0%(26例)、20.0%(10例),差异有统计学意义(χ~2值分别为4.244、5.657,均P<0.05)。观察组治疗期间不良反应发生率34.0%(17例),与对照组32.0%(16例)比较,无显著统计学差异(χ~2=0.045,P>0.05)。结论二甲双胍用于多囊卵巢综合征不孕症患者治疗可取得较佳疗效,胰岛素水平显著降低,有助于排卵,且不良反应发生率低,具有重要临床价值。Objective To observe the therapeutic effect of metformin on treatment of infertile patients with polycystic ovary syndrome and to evaluate its clinical value.Methods Altogether 100 cases of infertile patients with polycystic ovary syndrome treated in Xianyang Central Hospital of Shaanxi Province from January 2014 to June 2015 were selected as study objects,and they were divided into control group and observation group in accordance with paired grouping method with 50 cases in each group.Patients in the control group were treated with oral Diane-35,while patients in the observation group accepted metformin treatment based on treatment received in the control group.Patients in both groups were treated for 3 months,and efficacy was compared between two groups.Results There was no statistically significant difference in body mass index,luteinizing hormone and testosterone levels between two groups before treatment（t value was 0.869,1.534 and 1.153,respectively,all P〈0.05）.After treatment body mass index,luteinizing hormone and testosterone levels in the observation group were less than those in the control group,and indexes in two groups after treatment were lower than those before treatment（t value was 8.485,7.889 and 16.745,respectively,all P〈0.05）.Fasting blood glucose and 2 hblood glucose levels in two groups showed no significant difference before and after treatment（t value was 0.665 and 0.905,respectively,both P〈0.05）.After treatment fasting insulin and 2 hinsulin levels in the observation group were significantly lower than those in the control group and the indexes were lower than those before treatment（t value was 37.915 and 18.404,respectively,both P〈0.05）.After treatment ovulation and pregnancy were reported in36 cases（72.0%）and 21 cases（42.0%）,respectively in the observation group,which were significantly higher than in the control group（26 cases,52.0%;10 cases,20.0%）,and the differences were statistically significant（χ~2 value was 4.244 and 5.657,respectively,both

关 键 词：二甲双胍 多囊卵巢综合征 胰岛素 排卵 不良反应 

分 类 号：R711.75[医药卫生—妇产科学]