肠道菌群与甲状腺相关疾病的研究进展  

Intestinal flora and thyroid associated diseases

作　　者：王晓玮[1] 徐元宏[1] 

机构地区：[1]安徽医科大学第一附属医院,合肥230000

出　　处：《肿瘤代谢与营养电子杂志》2017年第3期349-352,共4页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：国家自然科学基金(81171606)

摘　　要：肠道菌群是由大量需氧菌、厌氧菌、病毒等组成,参与了机体许多生理功能的维持,与营养物质的消化吸收、免疫系统的调节、内分泌系统的激素代谢平衡有着至关重要的联系,二者相互作用,使宿主机体保持稳定。其与机体相关作用需要的信号物质可能是细菌相互作用的部分或其产生的代谢物,可作用于外源作用以及内生作用等。当肠道菌群出现紊乱时,机体可能出现一系列疾病。经研究许多内分泌及免疫相关疾病如1型糖尿病、2型糖尿病、炎症性肠炎、类风湿性关节炎等与肠道菌群紊乱多存在一定相关性。甲状腺作为机体重要的内分泌腺体,对于机体激素环境调节极其重要,作用复杂,同时甲状腺疾病种类多,发病过程中症状多较为复杂,机制尚不明确,如Graves病、桥本甲状腺炎、亚急性甲状腺炎等。本文通过对甲状腺相关疾病与肠道菌群紊乱之间的关联性研究进展作一综述,探究肠道菌群对于甲状腺疾病的预防、诊断以及治疗的指导意义。The intestinal flora is composed of a large number of aerobic and anaerobic bacteria, viruses and other components, which involved in maintaining many physiological function of the body. It has a crucial link with the balance of digestion, absorption, immune, endocrine and metabolic absorption and digestion of nutrients, in order to make the body remained stable. The signal substance required for the association of intestinal flora with the organism may be part of the bacterial interaction or the metabolite produced by itself. When the intestinal flora disorder, the body may appear a series of diseases. It has a connection between the endocrine and immune related diseases such as type 1 diabetes, type 2 diabetes, and inflammation Enteritis, rheumatoid arthritis and intestinal flora disorder. As a important endocrine gland, it has a certain correlation between thyroid and the body hormone regulation which acts an important role in complex environment. There are many different kinds of thyroid diseases, the pathogenesis of symptoms are complex, at the same time the mechanism is not very clear, such as Graves＇ s disease, Hashimoto＇s thyroiditis subacute thyroiditis, and so on. This article reviews the research progress of the relationship between the tyroid related diseases and disorders of the gut flora, in order to exploring the guiding significance of disease prevention, diagnosis and treatment.

关 键 词：肠道菌群 GRAVES病 桥本甲状腺炎 亚急性甲状腺炎 

分 类 号：R581[医药卫生—内分泌]