中医药对大肠癌血管生成的作用  

Effects of Traditional Chinese Medicine on Angiogenesis in Colorectal Cancer

作　　者：张曦 潘传芳[1] 胡兵[2] 沈克平[1] 

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]上海市中医药研究院中医肿瘤研究所,上海200032

出　　处：《中华中医药学刊》2017年第12期3043-3045,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81503430);上海市中医药领军人才项目(ZYSNXD-RC-LJRC)

摘　　要：血管生成是肿瘤生长、转移的重要基础,抗血管生成治疗已成为大肠癌常规治疗方式。研究显示丹参酮ⅡA、去甲斑蝥素和龙葵碱等中药单体,白花蛇舌草、半枝莲和白头翁等中药,健脾解毒方、健脾消癌方及藤龙补中汤等中药复方具有抑制大肠癌血管生成作用。在既有研究基础上,进一步发掘中医药资源,研发高效低毒的抗血管生成的中药制剂,对大肠癌的治疗具有重要意义。Angiogenesis is the basis of cancer metastasis and growth. Anti - angiogenesis therapy has become conven- tional treatment for colorectal cancer. Researches have shown that Chinese herbal compounds including Tanshinone IIA, Norcantharidin and Solanine, Chinese herbs such as Oldenlaadin diffusa, ScuteUaria barbara and Pulsatilla chinensis, and Chinese herbal formulae including Jianpi Jiedu Fang, Jianpi Xiaoai - Fang and Tenglong Buzhong Decoction can in- hibit angiogenesis in colorectal cancer. It is necessary to explore Chinese herb resources that are based on current studies to develop high - efficient and low - toxic anti - angiogenic herbal products that are important for colorectal cancer treatment.

关 键 词：大肠癌 血管生成 中医药 作用 机制 

分 类 号：R273[医药卫生—中西医结合] R735.34[医药卫生—中医肿瘤科]