泽泻汤对高脂血症大鼠LXRα和ABCA1表达的影响  

Effects on Lipid Metabolism and LXRα and ABCA1 mRNA Expressions of Rhizoma Alismatis Decoction in Rats with Hyperlipemia

作　　者：韩雪[1] 张睦清[2] 王茜[1] 王亚芬[3] 郝蕾[1] 刘宇[1] 石铖[1] 张一昕[1] 

机构地区：[1]河北中医学院,河北石家庄050200 [2]河北省中医院,河北石家庄050017 [3]河北医科大学,河北石家庄050017

出　　处：《中华中医药学刊》2017年第12期3107-3109,I0024,I0025,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(81503268);河北省高等学校科学技术研究项目(QN2015251);河北省中医药管理局科研计划项目(2015077);河北中医学院校内青年基金项目(QNZ2015002)

摘　　要：目的:观察泽泻汤对高脂血症大鼠肝组织肝X受体α(LXRα)和ATP结合转运子A1(ABCA1)表达的的影响,并探讨其作用机制。方法:复制高脂血症模型的同时给予泽泻汤高、低剂量及血脂康胶囊治疗,4周后,检测相关指标。结果:泽泻汤高、低剂量组大鼠血清TC、TG、LDL的含量明显降低,HLD的含量明显升高,同时肝组织LXRαmRNA表达和肝组织与小肠组织ABCA1蛋白的表达也明显增强。结论:泽泻汤增强LXRα/ABCA1的表达可能是其防治高脂血症的机制。Objective： To primarily discuss the mechanism of Rhizoma Alismatis Decoction on prevention and treatment of hyperlipemia through investigating hepatic expressions of LXR~ and ABCA1 mRNA in rats with hyperlipemia. Meth- ods ：The rats＇ model of hyperlipemia was duplicated by high- fat diet feeding. High and low dose of Rhizoma Alismatis Decoction, as well as Xuezhikang Capsule, was administrated in respectively designed groups, and corresponding indexes were detected 4 weeks later. Results - Rhizoma Ahsmatis Decoction could significantly reduce serum concentrations of TC, TG and LDL （ P 〈 0. 01 ） , while increasing the concentration of HDL （ P 〈 0. 01 ） and strengthening the expressions of LXRα and ABCAlmRNA （ P 〈 0. 01 ）. Conclusion： Strengthening expressions of LXRα/ABCA1 could be viewed as mechanisms of Rhizoma Alismatis Decoction on prevention and treatment of hyperlipemia.

关 键 词：泽泻汤 高脂血症 肝X受体Α ATP结合转运子Al 

分 类 号：R285.5[医药卫生—中药学]