肝炎后肝硬化继发肝癌患者小肝癌病灶320排CT灌注成像HAP、HPI、HPP变化及其临床意义  

Changes and clinical significance of HAP,HPI,and HPP in 320-slice CT perfusion imaging in small hepatocellular carcinoma secondary to liver cirrhosis induced by hepatitis

作　　者：廖碧红[1] 单鸿[2] 王劲[3] 周宏[1] 

机构地区：[1]南华大学附属第一医院,湖南衡阳421001 [2]中山大学附属第五医院 [3]中山大学附属第三医院

出　　处：《山东医药》2017年第40期14-17,共4页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(81430041);湖南省教育厅科研项目(17C1388)

摘　　要：目的观察肝炎后肝硬化继发原发性肝癌患者小肝癌病灶320排CT灌注成像肝动脉灌注量(HAP)、门静脉灌注量(HPP)、肝动脉灌注指数(HPI)变化,并探讨其临床意义。方法对20例肝炎后肝硬化继发原发性肝癌患者行320排CT肝脏动态容积灌注扫描,获得肿瘤组织及肝硬化组织的CT灌注值HAP、HPP、HPI。结果小肝癌病灶的HAP为(85.42±23.29)mL/(min·100 mL),HPP为(83.71±28.28)mL/(min·100 mL),HPI为(54.99±13.15)%;肝硬化组织的HAP为(26.88±10.02)mL/(min·100 mL),HPP为(158.99±23.80)mL/(min·100 mL),HPI为(15.57±5.95)%。小肝癌病灶和肝硬化组织HAP、HPI、HPP相比P均<0.05。结论与肝硬化组织比较,小肝癌病灶320排CT灌注成像HAP、HPI升高,HPP降低。320排CT灌注成像HAP、HPI、HPP有助于辅助诊断小肝癌。Objective To observe the changes of hepatic arterial perfusion （HAP）, portal vein perfusion （HPP）, and hepatic arterial perfusion index （ HPI） in 320-slice CT perfusion imaging of small hepatocellular carcinoma （ HCC） secondary to liver cirrhosis induced by hepatitis and to investigate its clinical significance .Methods Perfusion scans were performed with 320-slice CT in 20 patients with primary HCC secondary to liver cirrhosis induced by hepatitis .The CT per-fusion values of tumor tissues and liver cirrhosis tissues were obtained , including HAP, HPP, and HPI.Results In the HCC tissues, HAP was （85.42 ±23.29） mL/（min· 100 mL）, HPP was （83.71 ±28.28 ） mL/（min· 100 mL）, and HPI was 54.99%±13.15%;in the liver cirrhosis tissues, HAP was （26.88 ±10.02） mL/（min· 100 mL）, HPP was （158.99 ±23.80） mL/（min· 100 mL）, and HPI was 15.57%±5.95%.Significant differences were found in all the perfusion parameters between the HCC tissues and liver cirrhosis tissues （all P＆lt;0.05）.Conclusions Compared with the liver cirrhosis tissues, small HCC tissues have significantly higher HAP and HPI , and lower HPP in 320-slice CT perfusion imaging.The liver 320-slice CT perfusion imaging of HAP , HPP, and HPI is useful for monitoring the canceration of cir-rhosis nodules and providing supplementary information for the diagnosis of early HCC .

关 键 词：X线计算机体层摄影术 肝细胞癌 小肝癌 320排CT灌注成像 肝动脉灌注量 门静脉灌注量 肝动脉灌注指数 

分 类 号：R445.3[医药卫生—影像医学与核医学]