亲水性二芳基乙烯荧光分子开关的研究进展  

Research Progress on Hydrophilic Photoswitchable Fluorescent Diarylethenes

作　　者：李冲[1] 陈颖 谢诺华 刘俊霞[1] 范成 周岐元 朱明强[1] 

机构地区：[1]华中科技大学光学与电子信息学院武汉光电国家实验室,武汉430074

出　　处：《应用化学》2017年第12期1379-1402,共24页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(51673077;51603078;21474034);国家重点基础研究发展计划(2015CB755602;2013CB922104);中央高校基本科研业务费资助(HUST:2016YXMS029);武汉光电国家实验室主任基金(2016)资助~~

摘　　要：二芳基乙烯荧光分子开关因具有优良的抗疲劳性和双稳态特征而被广泛地研究与应用,亲水化成为其作为荧光开关探针走向应用的关键点之一。本文综述了亲水性二芳基乙烯荧光分子开关当前的研究进展,归纳了实现亲水性的几种重要途径和结构,分析了各种亲水化方法的优缺点,并着重介绍了亲水性二芳基乙烯荧光分子开关作为荧光开关探针在化学传感、生物传感、生物成像以及超分辨成像等领域的应用现状,并指出当前应用研究中存在的一些问题,同时也对其未来的应用前景进行了展望。Photoswitchable fluorescent dithienylethene is one kind of the most typical diarylethene structures. Hydrophilization of photoswitchable fluorescent dithienylethene has become one of the key factors to come true its practical applications as a fluorescence photoswitching probes. Owing to its excellent fatigue resistance and unique thermal bistability, it has been widely studied and applied. This paper reviews the development history of photoswitchable fluorescent thienylethenes, summarizes the mechanism of fluorescence photoswitching mechanisms, describes some important achievements on the foundational research about novel structures and improved properties of photoswitchable fluorescent thienylethene in recent years. We also focus on the systemic overview of the applications of photoswitchable fluorescent dithienylethylene in optical memory, non-destructive read-out, single-molecule fluorescence imaging, bio-imaging, all-optical transistors. In the end, the challenges encountered during the study of diarylethenes are analyzed. It is believable that photoswithcable fluorescent polymers based on dithienylethene is the research direction in the future. Moreover, the promising application of diarylethenes in super-resolution imaging is prospected.

关 键 词：二芳基乙烯 荧光分子开关 亲水性 传感 超分辨成像 荧光开关探针 

分 类 号：O644.1[理学—物理化学] O631[理学—化学]