超声造影即时评估对高强度聚焦超声治疗肝癌疗效及其生存率的影响研究  

Influence of contrast-enhanced ultrasound guided with high intensity focused ultrasound therapy on the curative effect and survival rate in patients with liver cancer

作　　者：赖小伟[1] 陈方红[1] 黄岩花[1] 

机构地区：[1]丽水市中心医院超声诊断科,浙江丽水323000

出　　处：《全科医学临床与教育》2017年第6期622-625,共4页Clinical Education of General Practice

基　　金：浙江省科学技术厅第四批重大科技专项(2013C03010);浙江省医药卫生科技计划项目(2015KYB453)

摘　　要：目的探究超声造影即时评估对高强度聚焦超声治疗肝癌的临床疗效及其生存率的影响。方法选择90例行高强度聚焦超声治疗肝癌患者,分为造影组和对照组各45例,造影组在超声造影引导下行高强度聚焦超声治疗肝癌,对照组则单纯应用高强度聚焦超声治疗肝癌。90例肝癌患者均随访2年。统计并比较两组病灶灭活率、病灶残留率、病灶遗漏率;治疗1个月后甲胎蛋白(AFP)变化及生存率。结果造影组患者的病灶灭活率明显高于对照组,而病灶残留率、病灶遗漏率明显低于对照组(χ~2分别=26.41、11.12、10.08,P均<0.05)。造影组患者的AFP值下降人数所占比例明显高于对照组,而升高人数所占比例、无变化人数所占比例明显低于对照组(χ~2分别=5.07、11.07、4.11,P均<0.05)。造影组患者6个月、1年、2年的生存率均明显高于对照组(χ~2分别=5.29、4.44、4.49,P均<0.05)。结论超声造影即时评估有助于提高高强度聚焦超声治疗肝癌的疗效,提高病灶整体灭活率及患者的生存率。Objective To explore the influence of contrast-enhanced ultrasound guided with high intensity focused ultrasound therapy on the curative effect and survival rate in patients with liver cancer. Methods Totally 90 patients with liver cancer who underwent high intensity focused ultrasound were selected and divided into the imaging group and the control group with 45 cases in each. The control group was given high intensity focused ultrasound therapy,and imaging group was given contrast-enhanced ultrasound guided with high intensity focused ultrasound therapy. 90 cases of liver cancer were followed up for 2 years. The inactivation rate,residual rate,and omission rate of the lesion,the change of the AFP value after 1 month,and survival rate between two groups were compared. Results The inactivation rate of the lesion of the imaging group was significantly higher than that of the control group,while the residual rate and omission rate of the lesion were significantly lower than those of the control group（χ~2=26.41,11.12,10.08,P〈0.05）. The proportion that the AFP value declines of imaging group was significantly higher than the control group,while the proportion of that the AFP value rise and did not change were significantly lower than the control group（χ~2=5.07,11.07,4.11,P〈0.05）. The survival rates of 6 months,1 year and 2 years of the imaging group were significantly higher than those of the control group（χ~2=5.29,4.44,4.49,P〈0.05）. Conclusion Contrast-enhanced ultrasound is helpful to improve the curative effect of high intensity focused ultrasound therapy on the patients with liver cancer and increase the inactivation rate of the lesion and the survival rate.

关 键 词：超声造影 高强度聚焦超声 肝癌 疗效 

分 类 号：R445.1[医药卫生—影像医学与核医学] R735.7[医药卫生—诊断学]