卡前列素氨丁三醇预防剖宫产后出血高危产妇的临床效果观察  

Preliminary study of carboprost tromethamine for reducing postpartum hemorrhage in high-risk caesarean section

作　　者：陈红燕[1] 张世昌[2] 陈黎[1] 

机构地区：[1]南京医科大学第一附属医院产科,南京210029 [2]南京医科大学第一附属医院检验科,南京210029

出　　处：《重庆医学》2017年第33期4628-4629,4632,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(81300507)

摘　　要：目的评价卡前列素氨丁三醇预防具有产后宫缩乏力高危因素产妇剖宫产后出血的临床效果。方法选择剖宫产后具有宫缩乏力高危因素的产妇150例,分为3组。A组在胎儿娩出后常规宫体及静脉注射缩宫素,B组在胎儿娩出后宫体注射卡前列素氨丁三醇,C组在胎儿娩出后宫体注射卡前列素氨丁三醇及静脉注射缩宫素。比较3组产妇术后2h及24h出血量、宫缩效果、生命体征及额外干预情况。结果 B组、C组术后2h及24h内出血量、血红蛋白及红细胞压积变化明显低于A组,宫缩效果较A组良好,需要的额外干预措施明显低于A组,差异有统计学意义(P<0.05)。B组、C组药物不良反应发生率高于A组。结论卡前列素氨丁三醇联合缩宫素可有效降低高危产妇剖宫产后的出血量,但用药期间需加强产妇生命体征监测。Objective To explore the effect of carboprost tromethamine in high misk cesarean section for preventing and reducing postpartum hemorrhage and their side-effect.Methods 150 women underwent cesarean section with high-risk postpartum hemorrhage were randomly divided into three groups：group A（50 cases only using oxytocin）,group B（50 cases only using carboprost tromethamine）and group C（50 cases using carboprost tromethamine and oxytocin）,which were injected medicine immediately after fetal disengagement.The blood loss（2 hand 24 h）,hemoglobin,hematocrit,uterine contraction,vital signs and extra treatment were compared among three groups.Results The amount of blood loss and the reduction of hemoglobin and hematocrit after the cesarean section in group B,C were obviously lower than that of group A（P〈0.05）.In group B and C,the rate of additional intervention was lower than group A.The incidence rate of side-effect in group B,C was notably higher than that of group A（P〈0.01）.Conclusion Carboprost tromethamine injection in caesarean section can effectively decrease the loss of bleeding,but the sideeffect of carboprost tromethamine should be focus on.

关 键 词：催产素 产后出血 剖宫产术 卡前列素氨丁三醇 

分 类 号：R719.8[医药卫生—妇产科学]