IPF合并肺气肿与未合并肺气肿患者的临床特点、肺功能、影像学及生活质量比较  

Comparison of clinical features,pulmonary function,imaging indexes and life quality between patients with IPF complicated by pulmonary emphysema and patients with IPF without pulmonary emphysema

作　　者：金蕊[1] 苗姝[1] 田惠媛[1] 佟金平[1] 

机构地区：[1]大连大学附属新华医院呼吸内科,辽宁省大连市116021

出　　处：《河北医药》2017年第24期3716-3718,共3页Hebei Medical Journal

基　　金：辽宁省科学技术研究与发展重点攻关项目(编号:102102345486)

摘　　要：目的探讨特发性肺间质纤维化(IPF)合并肺气肿和单纯肺间质纤维化患者临床特点、肺功能、影像学习和生活质量的差异。方法分析2014年2月至2015年8月接受治疗的70例IPF合并肺气肿(IPF合并肺气肿组)和80例单纯IPF(单纯IPF组)患者的临床资料。观察2组患者炎性因子、肺功能、影像学指标和生活质量的差异。结果 PF合并肺气肿组患者的IL-8、IL-17、hs-CRP和TNF-α水平均高于单纯IPF组(t=-51.543、-32.180、-11.545、-6.997,P<0.01);IPF合并肺气肿组患者FVC、FEV1、FEV1/FVC、MMEF和PEF水平均低于单纯IPF组(t=3.747、10.759、9.443、7.562、21.072,P<0.001);IPF合并肺气肿组患者的Sp O2水平低于单纯IPF组(P<0.01),PETCO2水平高于单纯IPF组(P<0.01);单纯IPF组患者除肢体疼痛外,生活质量各维度得分均高于IPF合并肺气肿组(P<0.01)。结论 IPF合并肺气肿患者的肺功能和生活质量均较单纯IPF患者差,且有明显的影像学特征。Objective To investigate the differences in clinical characteristics,pulmonary function,imaging indexes and life quality between the patients with idiopathic pulmonary interstitial fibrosis（ IPF） complicated by pulmonary emphysema and the patients with simple pulmonary interstitial fibrosis（ SIPF）. Methods The clinical data of 70 patients with IPF complicated by pulmonary emphysema（ IPF ＋ PE group） and 80 patients with SIPF（ SIPF group） who were treated in our hospital from February 2014 to August 2015 were retrospectively analyzed. The differences in inflammatory factors,lung function,imaging parameters and life quality were observed and compared between the two groups. Results The levels of IL-8,IL-17,hs-CRP and TNF-α in IPF ＋ PE group were significantly higher than those in SIPF group（ P 0. 01）,however,the levels of FVC,FEV1,FEV1/FVC,MMEF and PEF in IPF ＋ PE group were significantly lower than those in SIPF group（ P 0. 01）. The levels of Sp O2 in IPF ＋ PE group were significantly lower than those in SIPF group（ P 0. 01）,however,the levels of PETCO2 in IPF ＋ PE group were significantly higher than those in SIPF group（ P 0. 01）. Moreover except for limbs pain,the life quality scores in SIPF group were significantly higher than those in in IPF ＋ PE group（ P 0. 01）. Conclusion The pulmonary function and life quality of patients with IPF complicated by pulmonary emphysema are worse than those of patients with SIPF,with obvious imaging characteristics.

关 键 词：肺间质纤维化 肺气肿 肺功能 炎性因子 影像学特征 

分 类 号：R563.3[医药卫生—呼吸系统]