米索前列醇经直肠给药预防产后出血的临床疗效及安全性  

Clinical efficacy and safety of misoprostol in the prevention of postpartum hemorrhage by rectal administration

作　　者：张晋华[1] 

机构地区：[1]河南省汤阴县人民医院妇科,456150

出　　处：《临床医学》2017年第8期41-42,共2页Clinical Medicine

摘　　要：目的探讨米索前列醇经直肠给药预防产后出血的临床疗效及安全性。方法采用随机平行对照法将2015年1月至2016年2月103例分娩产妇分为对照组51例及观察组52例,对照组口服给药预防,观察组选择直肠给药方式。观察并比较两组治疗后2、24 h内出血量、产后出血例数及不良反应发生率。结果观察组2、24 h内出血量及出血发生率均低于对照组(P<0.05);观察组不良反应发生率为3.85%,低于对照组的15.69%(P<0.05)。结论米索前列醇经直肠给药预防产后出血效果显著,安全性高,值得临床进一步推广及应用。Objective To investigate the clinical efficacy and safety of misoprostol in the prevention of postpartum hemorrhage by rectal administration. Methods From January 2015 to February 2016,103 pregnant women were divided into control group（ 51 cases） and observation group（ 52 cases） according to a randomized parallel control method. The control group treated with misoprostol orally,the observation group was given misoprostol by rectal administration. The amount of bleeding,the number of postpartum hemorrhage and the incidence of adverse reactions were observed and compared between the two groups in 2 h and 24 h after treatment. Results In the observation group,the amount of bleeding and the incidence of adverse reactions in 2 h and 24 h were lower than those in the control group（ all P〈0. 05）. The incidence of adverse reactions in the observation group（ 3. 85%） was lower than that in the control group（ 15. 69%,P〈0. 05）. Conclusions Misoprostol in the prevention of postpartum hemorrhage by rectal administration has significant effect and high safety,worthy of further clinical promotion and application.

关 键 词：米索前列醇 直肠给药 产后出血 疗效 安全性 

分 类 号：R714.461[医药卫生—妇产科学]