血清甘胆酸、总胆汁酸、丙氨酸转氨酶、促甲状腺激素水平及中性粒细胞-淋巴细胞比率在妊娠期肝内胆汁淤积症诊断中的意义  

Diagnostic value of cholyglycine,serum bile acid,alanine transaminase,thyroid stimulating hormone,neutrophil-to-lymphocyte ratio in pregnant women with intrahepatic cholestasis of pregnancy

作　　者：刘开颜[1] 

机构地区：[1]江苏省南通市第三人民医院妇产科,226000

出　　处：《临床医学》2017年第9期16-18,共3页Clinical Medicine

摘　　要：目的探讨血清甘胆酸、总胆汁酸、丙氨酸转氨酶、促甲状腺激素水平以及中性粒细胞-淋巴细胞比率在妊娠期肝内胆汁淤积症诊断中的意义。方法将妇产科门诊妊娠期肝内胆汁淤积症孕妇48例和健康孕妇48例纳入课题研究,比较妊娠期肝内胆汁淤积(ICP)组孕妇和正常孕妇血清甘胆酸、总胆汁酸、丙氨酸转氨酶、促甲状腺激素水平以及中性粒细胞-淋巴细胞比率差异。结果 ICP组患者的血清甘胆酸、总胆汁酸、丙氨酸转氨酶、促甲状腺激素水平、中性粒细胞-淋巴细胞比率高于对照组,差异有统计学意义(P<0.05);同时,重度ICP组患者的血清甘胆酸、总胆汁酸、丙氨酸转氨酶、促甲状腺激素水平、中性粒细胞-淋巴细胞比率高于轻度ICP组患者,差异有统计学意义(P<0.05)。结论血清甘胆酸、总胆汁酸、丙氨酸转氨酶、促甲状腺激素水平以及中性粒细胞-淋巴细胞比率可以作为ICP诊断和轻度、重度分级的敏感指标。Objective To analyze the diagnostic value of cholyglycine（ CG）,serum total bile acid（ TBA）,alanine transaminase（ ALT）,thyroid stimulating hormone（ TSH）,neutrophil-to-lymphocyte ratio（ NLR） in pregnant women with intrahepatic cholestasis of pregnancy（ ICP）. Methods Forty-eight pregnant women with ICP and 48 healthy pregnant women were admitted. CG,TBA,ALT,TSH and NLR levels of the two groups of pregnant women were compared.Results CG,TBA,ALT,TSH and NLR levels of the ICP group pregnant women were significantly higher than those of control group,and the differences were significant（ P〈0. 05）; CG,TBA,ALT,TSH and NLR levels of the severe ICP group pregnant women were significantly higher than those of moderat ICP group,and the differences were significant（ P〈0. 05）.Conclusions The monitoring of CG,TBA,ALT,TSH and NLR levels have significant value for the diagnosis and mirld and severe classificathon as a sensitire of ICP.

关 键 词：甘胆酸 总胆汁酸 丙氨酸转氨酶 促甲状腺激素 中性粒细胞-淋巴细胞比率 妊娠期肝内胆汁淤积症 

分 类 号：R714.255[医药卫生—妇产科学]