老年慢性心力衰竭患者肌钙蛋白Ⅰ、超敏C-反应蛋白、氨基末端B型脑钠肽前体的变化及其预后评估价值  

Changes of Troponin Ⅰ,high sensitivity C reactive protein and N-terminal pro brain natriuretic peptide type B in elderly patients with chronic heart failure and its prognostic value

作　　者：王艳[1] 刘艳丽[1] 洪艳春 李毅[1] 

机构地区：[1]湖北医药学院附属东风总医院检验科,湖北十堰442008

出　　处：《中国卫生检验杂志》2017年第22期3279-3281,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨老年慢性心力衰竭患者cTnI、hs-CRP、NT-ProBNP的变化及其预后评估价值。方法选取2015年1月-2016年2月本院收治的76例老年慢性心力衰竭患者作为观察组,参照美国纽约心脏病协会(NYHA)心功能分级方案可分为Ⅰ级10例,Ⅱ级25例,Ⅲ级26例,Ⅳ级15例,另选取同期本院健康体检者50例作为对照组,比较2组cTnI、hs-CRP、NT-ProBNP水平,对观察组患者出院后随访1年,观察患者心血管事件的发生情况。结果观察组cTnI、hs-CRP及NT-ProBNP水平均高于对照组;Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级心功能患者的cTnI、hs-CRP及NT-ProBNP水平逐渐升高;19例患者发生心血管事件,55例患者未发生心血管事件,另有2例失访,发生心血管事件组的cTnI、hs-CRP及NT-ProBNP水平均高于未发生心血管事件组,以上差异均有统计学意义(P<0.05)。结论 cTnI、hs-CRP及NTProBNP能够较好地反映老年慢性心力衰竭患者的心功能,对病情及预后评估具有重要参考价值。Objective To investigate the changes of Troponin I（ cTnI）,high sensitivity C reactive protein（ hs-CRP） and N-terminal pro brain natriuretic peptide type B（ NT-ProBNP） in elderly patients with chronic heart failure and its prognostic value.Methods 76 elderly patients with chronic heart failure in our hospital from January 2015 to February 2016 were selected as the observation group,and according to the heart function classification program recommended by New York Heart Association（ NYHA）,they were divided into 10 cases of grade Ⅰ,25 cases of grade Ⅱ,26 cases of grade Ⅲ,15 cases of grade Ⅳ. 50 healthy elderly patients in our hospital were selected as the control group. The levels of cTnI,hs-CRP and NT-ProBNP were detected and compared between the two groups. The patients in the observation group were followed-up for 1 year after discharge,and the incidence of cardiovascular events were observed. Results The levels of cTnI,hs-CRP and NT-ProBNP in the observation group were higher than those in the control group; the levels of cTnI,hs-CRP and NT-ProBNP in patients in grade Ⅰ,gradeⅡ,grade Ⅲ and grade Ⅳ gradually increased; 19 patients had cardiovascular events,55 patients had no cardiovascular events,and another 2 cases were lost. The levels of cTnI,hs-CRP and NT-ProBNP in the cardiovascular event group were higher than that in the non cardiovascular event group,and the differences above were statistically significant（ P 〈0. 05）. Conclusion CTn I,hs-CRP and NT-ProBNP can better reflect the cardiac function in elderly patients with chronic heart failure,and have important reference value for the evaluation of the disease and prognosis.

关 键 词：慢性心力衰竭 老年人 肌钙蛋白Ⅰ 超敏C反应蛋白 氨基末端B型脑钠肽前体 

分 类 号：R541.4[医药卫生—心血管疾病]