多维评价抗颤止痉胶囊治疗帕金森病伴抑郁疗效研究  

Multi-dimensiona Effect Evaluation of Kangchan Zhijing Capsule in Treating Parkinson's Disease with Depression

作　　者：魏涛华[1] 杨文明[1] 鲍远程[1] 谢道俊[1] 韩辉[1] 童建兵[1] 

机构地区：[1]安徽中医药大学第一附属医院脑病中心,安徽合肥230031

出　　处：《中医药临床杂志》2017年第11期1867-1871,共5页Clinical Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局重大疑难疾病防治基金;安徽省人才开发基金(NO:2003Z026)资助

摘　　要：目的:应用抗颤止痉胶囊对帕金森病抑郁(Parkinson's disease with depression,PDD)血瘀风动证患者进行治疗,观察其对中医证候积分值、日常生活能力量表、抑郁自评量表、治疗副反应量表的影响,并总结超氧化物歧化酶活力、丙二醛浓度的变化,探索其在氧化应激方面的作用。方法:随机选取诊断符合PDD标准的患者60例,分成2组,同时予以抗震颤及多巴替代治疗,疗程56天。其中治疗组30例予以帕罗西汀联合院内制剂抗颤止痉胶囊,对照组仅用帕罗西汀。2组分别进行中医证候积分值、ADL(日常生活能力量表)、SDS(抑郁自评量表)、TESS(治疗副反应量表)量表测定,同时观察SOD活力、MDA水平指标变化。结果:治疗4周与疗前组内比较,日常生活能力量表分值增加,治疗8周分值显著增加(P<0.01)。2组治疗4周、8周分值增加比较有极显著差异(P<0.01)。2组治疗4周后抑郁自评量表分值均下降,治疗8周后抑郁自评量表分值治疗组下降明显,组内与组间比较均有统计学差异(P<0.05)。治疗2周后,2组治疗副反应量表分值有统计学差异(P<0.05),停药2周后,2组治疗副反应量表分值有显著差异(P<0.01)。治疗后各中医证候比较,肢体震颤、悲忧叹息、舌紫暗和/或夹瘀斑比较均有统计学意义(P均<0.05)。结论:抗颤止痉胶囊能改善帕金森病抑郁血瘀风动证患者的中医主要证候学表现,在改善日常生活能力、抑郁症状方面优于单纯抗抑郁治疗,治疗副反应小,其在减轻悲忧叹息、肢体震颤、舌紫暗和/或夹瘀斑方面疗效确切。Objective： The Kangchan Zhijing capsule was used to treat the patients with Parkinson＇s disease with depression（PDD）, and to observe the TCM syndrome score, daily living ability scale, depression self-rating scale,treatment side effects, and summarize the changes of superoxide dismutase（SOD） and malondialdehyde（MDA） concentrations,and explore its role in oxidative stress. Methods： 60 patients diagnosed as PDD were randomly selected and divided into two groups. The patients were treated with anti-tremor and dopa replacement therapy for 56 days. In the treatment group, 30 patients were treated with paroxetine combined with anti-epileptic and antispasmodic capsules in the hospital, and paroxetine in the control group. The scores of TCM syndromes, ADL（Daily life power scale）, SDS（Self-rating depression scale） and TESS（Treatment side effects scale） were respectively measured in 2 groups. The changes of SOD activity and MDA level were also observed. Results： Compared with the pre-treatment group, the scores of daily living ability scale increased 4 weeks after treatment, and the score of 8 weeks was significantly increased（P0.01）. There was a significant difference（P0.01） between the two groups in 4 weeks and 8 weeks. After 4 weeks of treatment, depression self-rating scale score decreased. After 8 weeks of treatment, the depression self-rating scale score decreased significantly in treatment group and there were significant differences between two groups（P0.05）.After 2 weeks of treatment, the two groups had statistically significant differences（P0.05）. After 2 weeks of treatment,the scores of two groups had significant differences（P0.01）. After treatment, TCM syndromes, limb tremor, sad sad sigh, dark purple tongue or ecchymosis were statistically significant（P0.05）. Conclusion： The Kangchan Zhijing capsule can improve the major TCM syndromes in patients with Parkinson＇s disease and depression and blood stasis, and is superior to simple antidepressant in impr

关 键 词：帕金森病 抑郁障碍 抗颤止痉胶囊 

分 类 号：R277.7[医药卫生—中医学]