脂肪因子Chemerin与多囊卵巢综合征的研究进展综述  

Review on Progress in Chemerin, an Adipokine, and Polycystic Ovarian Syndrome(PCOS)

作　　者：孙立峰[1] 杨雅莉[1] 黄晨 薛丽 张键[1] 

机构地区：[1]中国科学院深圳先进技术研究院生殖健研究康室,深圳518055

出　　处：《集成技术》2017年第6期59-71,共13页Journal of Integration Technology

基　　金：国家科技部973计划(2013CB945500);国家自然科学基金面上项目(31671562.00);深圳市基础研究学科布局(JCYJ20160331190714896)

摘　　要：多囊卵巢综合征(Polycystic Ovarian Syndrome,PCOS)是一种生殖和代谢功能紊乱疾病,发病率高、症状多样,对患者健康和生活造成多方面影响。临床上为了降低漏诊、误诊的发生率,先后提出了3个诊断标准:NIH(National Institutes of Health)标准、Rotterdam(European Society of Human Reproduction and Embryology,American Society for Reproductive Medicine)标准和AES(Androgen Excess Society)标准。在PCOS相关研究中,发现脂肪因子与PCOS具有相关性。脂肪因子由脂肪组织分泌,作为一类具有生物活性的物质,其功能涉及炎症反应、免疫活动、能量储备、脂肪细胞分化等多方面。其中,Chemerin作为一种新近发现并在PCOS患者体内异常表达的脂肪因子,在PCOS中的角色仍有待探索。综合现有信息可见,Chemerin在PCOS发生发展中具有作用,并可能成为PCOS新的治疗靶点。Polycystic ovarian syndrome is a disease with dysgenesis and metabolic disorders, which has the characteristics including the polycystic ovary and hyperandrogenism. In order to guide the diagnose the syndrome, three visions of diagnostic criteria were presented and implemented all over the world, the National Institutes of Health 1990 criteria, the Rotterdam 2003 criteria, and the Androgen Excess Society 2006 criteria. Many adipokines have effects on PCOS, which have the following biological fuctions, such as inflammatory response, immunoreaction, energy storage, and so on. Chemerin, a new adipokine, was found with higher concentration in PCOS patients, comparing the healthy, therole of which in the pathogenesis of PCOS was not clear. This review indicated the role of Chemerin in the pathological development which maintain the potential therapeutic target in PCOS

关 键 词：PCOS 雄激素 胰岛素 脂肪因子 CHEMERIN 

分 类 号：R711.75[医药卫生—妇产科学]