鲍曼不动杆菌的分离结果和耐药性分析  

Analysis of the isolation and drug resistance of acinetobacter baumann

作　　者：唐丽 赵建平 周秀岚[2] 

机构地区：[1]内蒙古自治区人民医院检验科,呼和浩特010010 [2]内蒙古医科大学附属医院药剂部,呼和浩特010050

出　　处：《内蒙古中医药》2017年第19期117-118,共2页Inner Mongolia Journal of Traditional Chinese Medicine

基　　金：2015年内蒙古自治区自然科学基金项目(2015MS08117)

摘　　要：目的:对2015年1月至2017年6月鲍曼不动杆菌的分离情况及耐药性进行分析,指导临床合理用药。方法 :回顾性分析2015年1月至2017年6月自内蒙古自治区人民医院分离出的899株鲍曼不动杆菌的标本来源、病区分布和耐药性。结果:鲍曼不动杆菌的病区分布主要为ICU、神经内科、神经外科、呼吸内科和干部保健病房,构成比分别为30.03%、15.57%、13.79%、12.79%和12.35%。标本来源主要为痰液,占所有标本的79.3%;其中鲍曼不动杆菌从痰液中检出的比例,神经外科和神经内科高达95.16%(118/124)和94.29%(132/140);干部保健病房较低为57.55%(97/111)。对碳青酶烯类耐药的鲍曼不动杆菌(CR-AB)的检出率为81.09%(729/899),高于既往文献报道2009年的4.00%,且差异有显著性(P<0.05)。除左旋氧氟沙星和复方新诺明的耐药率为31.48%(283/899)和57.03%(511/896)外,对其它10种抗菌药物的耐药率高达76~84%。复方新诺明的耐药率高于既往文献报道的2013年和2014年的27.1%和26.6%,且差异均有显著性(P<0.05)。值得一提的是,鲍曼不动杆菌对左旋氧氟沙星的中度敏感率高达48.94%(440/899),抗菌活性正由耐药性向敏感性转化。结论:鲍曼不动杆菌的分离率和耐药率较高,医院应加强对抗菌药物的管理使用,控制CR-AB在院内的感染和流行;实验室应做好细菌耐药性监测工作,定期分析CR-AB的检出率变化和耐药趋势,为临床和院感科提供有用的数据和结果。Objective：To analyze the isolation and drag resistance of the acinetobacter bauman from January 2015 to June 2017, and to guide the rational use of drugs. Methods A retrospective analysis of the source, distribution and drug resistance of 899 baunaann mycobacteria isolated from the people＇s hospital of Inner Mongolia autonomous region from January 2015 to June 2017. Results The distribution of the acinetobacter baumannei was mainly in ICU, neurology, nettrosurgery, respiratory medicine and cadre health care unit, which constituted 30.03%, 15.57%, 13.79%, 12.79% and 12.35% respectively.The source of the specimen was sputum, which accounted for 79.3% of all specimens.Among them, the proportion of the mycobacterium abacia was detected from sputum, neurosurgery and neurology were 95.16% （118/124） and 94.29% （132/140）.The lower level of cadre health care unit was 57.55% （97/111）. The detection rate of cr-ab was 81.09% （729/899）, higher than the previous literature reported in 2009, and the difference was significant （P 〈 0.05）.The drug resistance rate of the other 10 antimicrobial agents was 76-84 %, except that the tolerance rate oflevofloxacin and compound new norming was 31.48% （283/899） and 57.03% （511/896）.The drug resistance rate of compound new norming was higher than that of the previous literature, 27.1% and 26.6% in 2013 and 2014, and the difference was significant （P 〈 0.05）.It is worth mentioning that the moderate sensitivity of acinetobacter baumannii to levofloxacin is as high as 48.94% （44/899）, and antimicrobial activity is transformed from resistance to sensitivity. Conclusion The separation rate and drug resistance rate of acinetobacter baumarmii are high, and the hospital should strengthen the management and use of antimicrobial agents, and control the infection and popularity of cr-ab in the hospital.The laboratory should be responsible for the monitoring of bacterial resistance, analyze the detection rate and drug resistance trends of cr-ab regularly, an

关 键 词：鲍曼不动杆菌 亚胺培南 碳青酶烯类耐药的鲍曼不动杆菌 耐药性 

分 类 号：R285.6[医药卫生—中药学]