辅酶Q_(10)生物合成方法的研究进展  

Current Status of CoQ_(10) Biosynthesis in Microoganisms

作　　者：陈有为 陈学端 丁点寒 邹丽梅 祁峰[1] 黄建忠[1] 

机构地区：[1]福建师范大学生命科学学院,福建福州350108

出　　处：《药物生物技术》2017年第5期431-435,共5页Pharmaceutical Biotechnology

基　　金：国家自然科学基金(No.21406130);福建省自然科学基金(No.2016J01148)

摘　　要：辅酶Q_(10)由醌环母核和聚异戊二烯疏水侧链组成,在电子传递链中起传递电子的作用。因其有抗脂质过氧化,参与细胞能量代谢和基因表达调控等功能备受研究者的关注。微生物法生产CoQ_(10)具有产物活性高、原料成本低并可以通过规模放大提高生产能力等优点。因此清楚微生物法生产CoQ_(10)的生物合成途径,关键酶基因以及能够提高CoQ_(10)产量的发酵条件优化的方法策略对大规模工业化生产CoQ_(10)具有重要参考意义。CoenzymeQ_（10）（CoQ_（10））,known as ubiquinone,is formed by the conjugation of a benzoquinone head group and a tail of ten repeated isoprene units. CoQ_（10） plays multiple roles,such as participating in aerobic respiration and functioning as an electron carrier in the electron transfer system. In addition,it is also well known as an antioxidant and has been found to be beneficial in treatment and prevention of mitochondrial diseases and arterial hypertension. Owing to these unique properties,CoQ_（10） is garnering increasing interests of researchers in a variety of fields with the common aim of improving its production. The biosynthesis route of CoQ_（10） in prokaryotes can be decomposed to three units： methylerythritol phosphate（MEP） pathway,shikimate pathway and ubiquinone pathway.Thus many strategies for enhancing CoQ_（10） production have been developed in various microorganisms to promote the industrial application of CoQ_（10）.

关 键 词：辅酶Q10 对羟基苯二甲酸 异戊二烯焦磷酸 生物合成途径 关键酶 

分 类 号：Q552[生物学—生物化学]