B细胞来源的IL-35对慢性乙型肝炎患者HBeAg状态的影响  

Effects of Il-35 on the State of HBe Ag in Patients with Chronic Hepatitis B

作　　者：梁敏锋[1] 严海明[1] 林小清[1] 周惠玲[1] 刘全妹[1] 白红莲[1] 

机构地区：[1]广东省佛山市第一人民医院感染科,广东佛山528000

出　　处：《黑龙江医药》2017年第6期1199-1201,共3页Heilongjiang Medicine journal

基　　金：佛山市医学类科技攻关项目(项目编号:2016B070)

摘　　要：目的:分析B细胞来源的IL-35对慢性乙型肝炎HBeAg状态的影响。方法:测定E抗原阳性、阴性慢性乙型肝炎患者和健康人员血清、肝组织IL-35、CD138+IL-35+B细胞频数、HBV抗原的表达水平。结果:实验组A血清IL-35为(76.94±8.99)pg/ml,高于其他两组的(56.25±6.70)pg/ml、(29.27±5.54)pg/ml(P<0.05),外周血CD138+IL-35+B细胞频数大于实验组B(P<0.05),肝组织IL-35、HBV抗原表达水平高于实验组B(P<0.05)。结论:B细胞来源IL-35水平升高是导致慢性乙型肝炎患者HBeAg呈阳性的主要原因。Objective: To analyze the effects of il-35 on the status of HBeAg in chronic hepatitis B. Methods: To determine the expression level of E antigen positive, negative chronic hepatitis B patients and health personnel serum, liver tissue il-35, CD138 + il-35 + B cell frequency, HBV antigen. Results: The experimental group A serum IL-35 for pg/ml(76.94 + 8.99), higher than the other two groups of pg/ml(56.25 + 6.70),(29.27-5.54 pg/ml)(P<0.05), peripheral blood CD138 + IL-35 + B cells frequency greater than group B(P<0.05), liver tissue IL-35, HBV antigen expression level was higher than group B(P<0.05). Conclusion: The increase of il-35 in B cell source is the main reason for HBeAg positive in patients with chronic hepatitis B.

关 键 词：B细胞 慢性乙型肝炎 HBV IL-35 HBeAg状态 

分 类 号：R512.62[医药卫生—内科学]