高危型HPV感染导致宫颈癌发生的风险评估  

Evaluation of high-risk human papilloma virus infection inducing cervical cancer

作　　者：刘建华[1] 王萍[2] 

机构地区：[1]上海交通大学医学院附属第九人民医院妇产科,上海200011 [2]上海中医药大学附属曙光医院妇产科,上海200021

出　　处：《医学研究生学报》2017年第12期1233-1237,共5页Journal of Medical Postgraduates

摘　　要：人乳头瘤病毒(HPV)感染致瘤的机制已经被阐明,高危型HPV感染可导致恶性肿瘤的发生,如宫颈癌等。宫颈高危型HPV感染常见,然而仅有少数发生恶性肿瘤,因此对其感染后致瘤风险的评估具有重要临床意义。高危型HPV持续感染是肿瘤发生的前提,机体的免疫功能失调是导致HPV不能被及时清除而造成持续感染的主要原因,病毒的类型是导致被感染的上皮细胞癌变的重要因素。The oncogenic mechanism of human papilloma virus( HPV) has been elucidated,and high-risk HPV( HR-HPV)infection may cause malignancies such as cervical cancer. HR-HPV infection of the cervix is very common,while only a few cases of such infection develop into malignancy. Therefore,the evaluation of oncogenic risk of cervical HPV infection is of great clinical significance. Persistent HR-HPV infection of the cervix is mainly caused by immunological dysfunction-induced failure of HPV elimination and supposed to be the precondition of cervical cancer,while the type of HPV is an important factor for carcinogenesis of epithelial cells.

关 键 词：人乳头瘤病毒 宫颈癌 免疫功能 肿瘤发生 

分 类 号：R373.9[医药卫生—病原生物学]