女性及其男性性伴侣HPV感染状况及型别分析  

Human papilloma virus infection and genotype analysis in females and their male sexual partners

作　　者：谢莉莉[1] 任虹[2] 刘忠伦[2] 谈笑[1] 

机构地区：[1]蚌埠医学院附属连云港市东方医院皮肤科,连云港医学硕士研究生222042 [2]连云港市第一人民医院皮肤科,连云港222002

出　　处：《医学研究生学报》2017年第12期1260-1263,共4页Journal of Medical Postgraduates

基　　金：蚌埠医学院研究生科研创新计划项目(Byycx1521);连云港市社会发展计划项目(SH1421)

摘　　要：目的人乳头瘤病毒(HPV)感染可致宫颈癌等多种恶性肿瘤,控制HPV感染极为重要。文中旨在探讨女性及其男性性伴侣HPV感染状况基因型分布,为制定HPV防控措施提供依据。方法收集2015年12月至2016年5月在连云港市第一人民医院及连云港市东方医院皮肤科HPV阳性的110例女性患者及其男性性伴侣。采集女性患者的宫颈脱落细胞及其男性性伴侣尿道口上皮细胞,并进行HPV分型检测,对结果进行分析。结果 110例女性患者中单一型别感染患者68例(61.82%),多重型别感染患者42例(38.18%)。110例男性性伴共检测到HPV感染37例,感染率33.64%,单一型别感染23例(62.16%),多重型别感染14例(37.84%)。HPV感染的男性共检测出HPV型19种,高危HPV型别出现频次39次(65%),低危HPV型别出现频次21次(35%)。性伴双方HPV吻合率为54.05%,完全及部分吻合率均为27.03%。结论HPV感染女性的男性性伴有较高的HPV感染率且男女双方型别一致性高;对男性进行HPV干预,常规开展男性HPV检测具有重要意义。Objective Human papilloma virus( HPV) infection can cause cervical cancer and other malignancies,so it is of vital importance to control HPV infection. The article was to investigate HPV prevalence and genotype distribution among females and their male partners in order to provide a basis for HPV prevention and control measures. Methods From Dermatology Departments of the First People's Hospital of Lianyungang City and Lianyungang Oriental Hospital during December 2015 and May 2016,we collected110 females identified with HPV-positive by HPV detection of cervical epithelial cells and their typing results. Cervical exfoliative cells of female patients and urethral epithelial cells of their male sexual partners were collected for HPV typing test and genotype analysis.Results Among the cases,there were 68 cases of single gene type infection( 61. 82%),42 cases of multiple infections occurred( 38.18%). As to their male partners,37 cases were detected HPV positive( 33.64%),among which 23 cases were single gene type infection( 62.16%),and 14 cases were multiple infection( 37.84%).There were 21 HPV types in the detection of 110 HPV-infected females. There was significant statistical difference in the frequency of high-risk and low-risk HPV gene types between males and females( 21 times vs 41 times,P<0.05). The HPV anastomosis rate between sexual partners was 54. 05%( 20/37),and the complete and partial coincidence rate was 27. 03%( 10/37). Conclusion The male partners of HPV-infected females has high rate of HPV infection and they both have high type consistency. Therefore,it is necessary to control HPV infection in males and regular male HPV detection is very important.

关 键 词：人乳头瘤病毒 男性伴侣 感染 基因型 

分 类 号：R446.5[医药卫生—诊断学]