痰热清联合舒利迭对慢性阻塞性肺病急性加重患者炎症氧化应激反应的影响  

Effect of Tanreqing combined with seretide on oxidative stress in patients with AECOPD and its clinical efficacy

作　　者：刘楠[1] 李凯[1] 王君兰[1] 邬亭亭[1] 

机构地区：[1]成都市第三人民医院,成都610000

出　　处：《陕西中医》2017年第12期1649-1651,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：四川省卫生和计划生育委员会科研课题(17PJ381)

摘　　要：目的:观察痰热清联合舒利迭对慢性阻塞性肺病急性加重(AECOPD)患者炎症氧化应激反应的影响,评价临床疗效。方法:116例AECOPD患者使用随机数字表法分为对照组和治疗组。观察两组患者治疗前后8-异前列腺素F2α(8-iso-PGF2α)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血气分析和肺功能指标的变化。比较两组治疗后临床症状和治疗有效率的差异。结果:治疗后治疗组PaO_2、PaCO_2、FEV1%和FEV1/FVC均高于对照组(P<0.05)。治疗组呼吸困难消失时间、啰音消失时间和住院时间分别(2.8±0.5)d、(3.9±0.7)d和(7.2±1.3)d,均显著低于对照组的(3.6±0.7)d、(5.2±0.9)d、(10.9±2.1)d(P<0.05)。治疗组临床治疗有效率为89.7%(52/58)高于对照组的74.1%(43/58)(P<0.05)。治疗后治疗组8-iso-PGF2α、IL-6和TNF-α因子表达均低于对照组(P<0.05)。结论:痰热清联合舒利迭显著减轻AECOPD患者氧化应激损伤,临床疗效较好。Objective:To observe the effect of Tanreqing combined with Seretide on oxidative stress in patients with AECOPD and explore its clinical efficacy.Methods:116 AECOPD patients were divided into control group and Tanreqing combined with Seretide treatment group.The expression of 8-iso-PGF2α,IL-6,TNF-α,blood gas analysis and pulmonary function index was recorded.The clinical symptoms and treatment efficiency was compared between the two groups.Results:After treatment,the improvement of PaO_2,PaCO_2,FEV1%,and FEV1/FVC was better in treatment group than that in control group(P<0.05).The disappearance time of breath difficult,wheeze relief time and hospital during time was(2.8±0.5)d,(3.9±0.7)d,(7.2±1.3)d in treatment group,which was shorter than that of(3.6±0.7)d,(5.2±0.9)d,(10.9±2.1)d in control group(P<0.05).The treatment efficiency was 89.7%in treatment group,which was better than 74.1%in control group(P<0.05).There was no significant difference of 8-iso-PGF2α,IL-6,and TNF-αbetween the two groups before treatment(P>0.05).After treatment,the improvement of 8-iso-PGF2α,IL-6,and TNF-αwas better in treatment group than that in control group(P<0.05).Conclusion:Tanreqing combined with Seretide could significantly reduce oxidative stress damage in AECOPD patients,with effectively clinical curative effect.

关 键 词：肺疾病 慢性阻塞性/中西医结合疗法 @痰热清 炎症 

分 类 号：R563[医药卫生—呼吸系统]