三乙胺催化微波法合成乙酰水杨酸实验研究  

On Experiment of Synthesis of Aceylsalicylate under Microwave Irradiation with Triethylamine as Catalyst

作　　者：管晓渝[1] 李尔康 刘章琴[1] 马学兵[1] 

机构地区：[1]西南大学化学化工学院,重庆400715 [2]西南大学附属中学,重庆400715

出　　处：《西南师范大学学报（自然科学版）》2017年第11期184-187,共4页Journal of Southwest China Normal University(Natural Science Edition)

基　　金：高等学校博士学科点专项科研基金(20130182120012);中央高校基本科研业务费专项资金资助(XDJK2014C037;XDJK2015C021);西南大学教育教学研究项目(2016JY104)

摘　　要：普通高等院校本科"有机制备"实验课程中乙酰水杨酸的制备方法,由于采用浓硫酸作催化剂和传统加热法,具有操作复杂、耗时、副反应多、难以纯化和环境污染严重等缺点.以三乙胺为催化剂,用微波合成法快速制备乙酰水杨酸.通过系统地研究物料比、催化剂用量、微波功率、反应温度和时间等实验条件对乙酰水杨酸产率的影响,获得一套高效、绿色的乙酰水杨酸的制备方案.The synthetic method of acetylsalicylate with catalysis of concentrated sulfuric acid under thermal condition described in ＂Organic Synthesis＂course has the drawbacks of complicated operation,timeconsuming,more side reactions,difficult to purification,environment pollution.In this paper,acetylsalicylate has been synthesized with trimethylamine as catalyst under microwave irradiation.Reaction conditions such as molar ratio of starting material,catalyst loading,reaction time and temperature,microwave power have been investigated.Hence,a relatively effective and environmental friendly experimental method for the＂organic synthesis＂course is recommended for the synthesis of acetylsalicylate.

关 键 词：乙酰水杨酸 三乙胺 催化合成 微波辐射 

分 类 号：G642.423[文化科学—高等教育学]