基于ARM单片机全自动连续微球制备仪的研制  

Development of an automatic and continuous microspheres preparation instrument based on ARM microcontroller

作　　者：田寒梅[1] 侯延进[1] 王建梅[1] 李艳[1] 王雪莹[1] 王建春 许敏[1] 王立秋[1,2] 

机构地区：[1]山东省科学院能源研究所传递现象研究中心,山东济南250014 [2]香港大学机械工程系,中国香港999077

出　　处：《山东科学》2017年第6期94-98,共5页Shandong Science

基　　金：山东省重点研发项目(2015GSF121048);山东省科学院先导专项;山东省科学院青年基金(2016QN006);国家自然科学基金(20165094);山东省自然科学基金博士基金(ZR2016BB15);2015年山东省科学院院基础基金;山东省自然科学三院联合基金(ZR2015YL006)

摘　　要：微球在药物合成及释放等诸多领域应用广泛,利用传统的高剪切乳化技术如相分离法、沉淀法等制备出的微球存在尺寸分布广、结构不可控的缺点。本文研制了一款基于微流控技术的全自动连续微球制备仪,该仪器以ARM系列STM32F407型单片机作为核心控制其各个执行模块的动作,同时单片机与触摸屏PC机进行数据交换处理,实现了全自动连续制备微球的功能。测试结果表明,仪器连续工作80 h工作稳定,且制备出的微球粒径均匀、结构可控。Microspheres cover a wide range of applications such as drug synthesis and release. Microspheres fabricated by conventional high-sheer emulsification techniques, for instance phase separation and precipitation, have the defects of a large polydispersity in size and a high variability in structure. However, droplet microfluidic technology can overcome the problems. In this paper, based on microfluidic technology, an instrument was developed for precisely synthesizing microspheres in an automatic and continuous manner. The STM32F407 microcontroller of ARM series was the core of the instrument, which controlled the action of each execution module and communicated data with PC touching-screen. Results show that the instrument can work continuously for 80 hours, and enables an automatic and continuous preparation of microspheres with uniform and well-controlled size.

关 键 词：微流控技术 ARM单片机 全自动微球制备仪 

分 类 号：TP273[自动化与计算机技术—检测技术与自动化装置]