艾地苯醌对脑出血后疲劳的治疗作用  

The Effect of Idebenonerelieves on Fatigue After Intracerebral Hemorrhage

作　　者：李隆龄[1] 王蓉[1] 王凤[1] 陈中杰[1] 阳清伟[1] 

机构地区：[1]厦门大学附属中山医院神经内科,福建厦门361004

出　　处：《中国卫生标准管理》2017年第26期76-78,共3页China Health Standard Management

摘　　要：目的脑出血后疲劳很常见,会降低脑出血后生活质量。现将艾地苯醌对脑出血后疲劳的治疗作用做一初步探讨。方法试验为随机、双盲和安慰剂对照。纳入脑出血患者用90 mg艾地苯醌或安慰剂治疗90天,评估入院时、30天、90天和180天疲劳水平、神经功能、残障水平、焦虑和抑郁状态、嗜睡状态。主要终点是180天疲劳状态。结果 241例脑出血患者完成了试验和随访,艾地苯醌治疗131例。相比对照组,180天艾地苯醌组的患者疲劳水平下降(P<0.05),90天、180天焦虑、抑郁发生率更低(P<0.05),30天、90天、180天嗜睡程度降低(P<0.05)。结论艾地苯醌缓解脑出血后疲劳,此治疗效果独立于焦虑、抑郁、残障的改善。Objective Fatigue is common and it reduces quality of life after intracerebral hemorrhage.This trial is to investigate the treatment of fatigue after intracerebral hemorrhage with idebenone.Methods The trial was randomized,double-blinded,and placebo-controlled.Patients with acute intracerebral hemorrhage were treated with 90 mg idebenone or placebo for 90 days.FAS,NIHSS,m RS,HADS and ESS assessments were done at inclusion,30,90 and 180 days.The primary end point was fatigue at 180 days measured by FAS.Results 241 patients had been followe dupcompletely.131 patients were treated with idebenone.Compared with the control group,idebenonedecreased fatigue at 180 days significantly.In addition,idebenone group obtained better scores on the FAS（P〈0.05） after 30 and 90 days,reduced HADS scores（P〈0.05） after 90 and 180 days,and significant decreased ESS scores（P〈0.05） after 30,90 and 180 days.Conclusion Idebenonerelieves fatigue after intracerebral hemorrhage.The treatment effectis independent of the improvement of anxiety,depression and disability levels.

关 键 词：脑出血 疲劳 艾地苯醌 康复 

分 类 号：R971[医药卫生—药品]