阿奇霉素与β-内酰胺类抗生素治疗小儿肺炎临床有效性及安全性比较  

Comparison of Clinical Efficacy and Safety of Azithromycin and β-Lactam Antibiotics in Children With Pneumonia

作　　者：陈叶莉 

机构地区：[1]厦门大学附属第一医院药学部,福建厦门361003

出　　处：《中国卫生标准管理》2017年第26期93-95,共3页China Health Standard Management

摘　　要：目的对肺炎患儿采取阿奇霉素或β-内酰胺类抗生素治疗的临床疗效和安全性进行研究。方法选取2016年1—12月来我院就诊的1~5岁肺炎患儿100例,按照随机数字表法将其分为实验组和对照组,各组50例。将使用β-内酰胺类抗生素治疗的患儿作为对照组,将使用阿奇霉素治疗的患儿作为实验组。对两组临床有效性及安全性进行比较。结果实验组肺炎患儿肺部湿罗音消失时间、住院时间相比于对照组肺炎患儿,明显较短(P<0.05);实验组患儿的临床效果优于对照组(P<0.05)。对比两种治疗方法的费用,差异有统计学意义(P<0.05)。对比两组不良反应发生率和痰细菌培养结果,差异性无统计学意义(P>0.05)。结论对肺炎患儿采取阿奇霉素治疗,改善了患儿的肺部湿罗音吸收时间,取得明显的治疗效果,缩短了住院时间,具有一定的安全性。Objective To study the clinical efficacy and safety of azithromycin andβ-lactam antibiotics in children with pneumonia.Methods 100 cases of children who were 1 ~ 15 years old with pneumonia were enrolled in our hospital from January to December 2016.They were divided into experimental group and control group according to the random number table method.The children treated with β-lactam antibiotics were used as the control group,and children treated with azithromycin were used as experimental groups.The clinical efficacy and safety of the two groups were compared.Results The moist rale disappear time and hospitalization time of lung pneumonia children in experimental group were significantly shorter than those in control group（P〈0.05）.The clinical effect of experimental group was better than the control group（P〈0.05）.There was difference in the cost of two kinds of treatment methodof the two groups（P〈0.05）.There was no difference in the incidence of adverse reactions and the results of sputum culture between the two groups（P〈0.05）.Conclusion The use of azithromycin in children with pneumonia,can improve children＇s lung moist rale absorption time,and obtain significant treatment effect,and shorten the hospital stay time,with a certain degree of safety.

关 键 词：湿罗音消失时间 阿奇霉素 Β-内酰胺类抗生素 小儿肺炎 安全性 

分 类 号：R974[医药卫生—药品]