发硒含量与燃煤型砷中毒病情的关系研究  

Relationship between hair selenium and arsenism induced by arsenic derived from coal combustion

作　　者：韦炳干[1] 高健伟 孔畅 杨林生 李海蓉[1,3] 虞江萍 夏雅娟[4] 武克恭 

机构地区：[1]中国科学院地理科学与资源研究所陆地表层格局与模拟院重点实验室,北京100101 [2]中国核电工程有限公司,北京100840 [3]中国科学院大学资源与环境学院,北京100049 [4]内蒙古综合疾病预防控制中心,呼和浩特010031

出　　处：《中华地方病学杂志》2017年第12期866-869,共4页Chinese Journal of Endemiology

基　　金：国家自然科学基金（41230749、41601559）

摘　　要：目的探讨陕南燃煤型砷中毒病区内人群发硒含量与砷中毒病情的关系。方法以陕南燃煤型砷中毒病区4个高砷暴露村为研究区，并选择附近非砷暴露村为对照区。采集研究区内居民发样90份，对照区居民的发样14份．电感耦合等离子体质谱仪（ICP—MS）测定发硒和发砷含量，计算发硒／发砷值，分析人群发硒含量与砷中毒病情的关系。结果研究区居民的发硒含量几何平均值为8．72mg／kg，高于对照区人群发硒含量（0．54mg／kg，t=9．811，P〈0．05），但未发现硒中毒病例。发硒含量与砷中毒无相关性（r=0．075，P〉0．05），而发硒／发砷值随砷中毒病情加重而减少（P〈0．05）。女性的发硒含量为12．79mg／kg，高于男性（6．50mg／kg，t=1．738，P〈0．01），同时女性发硒／发砷值（1．15）也高于男性（0．65，t=3．218，P〈0．05）。结论陕南燃煤型砷中毒病区同时存在高硒环境污染，砷和硒的拮抗作用降低了硒的毒性，这可能是当地末出现硒中毒病例的原因，也可能是病区的女性砷中毒患病牢低于男性的原因。Objective To study the relationship between hair selenium content and arsenism among population from endemic： arsenism area caused by coal combustion in the southern of Shaanxi Province. Methods Four high-arsenic-exposed villages in southern Shaanxi Province were selected as the study area, and the non- arsenic：-exposed villages nearby were selected as the control area, 90 hair samples of residents exposed to high arsenic in the study area and 14 hair samples of residents in the control area were collected. Inductively Coupled Plasma Mass Spectrometry （ICP-MS） was used to determine the contents of arsenic and selenium in hair samples. Selenium/hair arsenic （Se/As） value was calculated, and the relationship between selenium content in hair samples and arsenicosis was analyzed. Results The geometric mean of selenium concentration in hair from the study area was 8.72 mg/kg, which was significantly higher than that from the control area （0.54 mg/kg, t = 9.811, P 〈 0.05）. However, selenosis case was not found in the study area. Selenium content in hair was not obviously correlated with arsenism （r = 0.075, P 〉 0.05）, while the Se/As value was negatively associated with the grade of arsenism （P 〉 0.05）. The geometric mean of selenium content in hair of female from the study area was 12.79 mg/kg, which was higher than that in hair of male （6.5 mg/kg, t = 1.738, P 〈 0.01）. Meanwhile, the Se/As value in hair of female from the study area （1.15） was significantly higher than that in hair of male （0.65, t = 3.218, P 〈 0.05）. Conclusions The environment of the study area is polluted by arsenic and selenium derived from stone-coal burning. Antagonism between arsenic and selenium might reduce the toxicity of selenium. Therefore, selenosis is not found in the study area. In addition, antagonism between arsenic and selenium might also induce lower prevalence of arsenism for female in the study area.

关 键 词：砷中毒 硒 头发 石煤 

分 类 号：R599.1[医药卫生—内科学]