基于双气相定量CT评估无症状青年女性空气潴留程度的研究  

Evaluation of air trapping in lung using biphasic quantitative CT in young asymptomatic females

作　　者：梁志冉[1] 师美娟[1] 段海峰 许兵强 王红梅[1] 佟佳音 金晨望[1] 郭佑民[1] 

机构地区：[1]西安交通大学第一附属医院影像科,陕西西安710061 [2]陕西中医药大学附属医院影像科,陕西咸阳712000

出　　处：《实用放射学杂志》2017年第12期1831-1835,共5页Journal of Practical Radiology

基　　金：国家卫生和计划生育委员会公益性行业科研专项基金（20142013）.

摘　　要：目的 评估无症状青年女性空气潴留程度和分布，为小气道病变的早期诊断奠定基础。 方法 回顾性纳入50例肺功能正常青年女性，行呼、吸双相CT扫描，定量分析空气潴留百分比（AT）和肺气肿百分比（Emph）。两肺间比较用独立样本t检验，各肺叶间用单因素方差分析或Kruskal-Wallis秩和检验、肺叶两两比较用LSD或成对比较，各肺叶对AT的影响用Spearman相关、简单线性回归和多元逐步回归进行分析。结果 无症状青年女性存在一定程度空气潴留和少量肺气肿，空气潴留主要分布在右肺中叶（RML）和两肺上叶，且RML空气潴留与RML体积比例最高，两肺上叶空气潴留变化对全肺空气潴留程度影响最大。结论 无症状青年女性中也存在一定程度的空气潴留，RML空气潴留发生、发展可能是影像学早期监测小气道疾病病理生理变化的敏感生物学标记。Objective To evaluate the extent and anatomic distribution of air trapping in lung in young asymptomatic female subjects to achieve early diagnosis of small airway diseases. Methods Fifty young females with normal pulmonary function were included retrospectively in this study. All subjects underwent both inspiratory and expiratory CT scans, the percentage of the area of air trapping （ AT） and the percentage of the area of emphysema （ Emph） were quantitatively analyzed. Comparison between bilateral lungs was analyzed using independent-samples t test; Comparisons among lobes were done using one-way ANOVA or Kruskal-Wallis rank sum test; Pairwise comparisons between lobes were conducted using LSD test or paired comparison;The effects of each lobe on AT were analyzed using Spearman＇s rank correlation coefficient, simple linear regression and multiple stepwise regression.Results There was a certain degree of air trapping in lung and a small amount of emphysema in young asymptomatic females. Air trapping was mainly located in the right middle lobe （ RML） and bilateral upper lobes.The ratio of air trapping to volume was the highest in RML and the change of air trapping in the bilateral upper lobes had the greatest influence on the air trapping degree of the whole lung.Conclusion There is a certain degree of air trapping in lung in young asymptomatic females.The occurrence and development of air trapping in RML may be a sensitive biomarker for the early detection of pathophysiological changes in small airway diseases using imaging procedures.

关 键 词：小气道病变 空气潴留 无症状青年 计算机体层成像 

分 类 号：R562[医药卫生—呼吸系统] R814.42[医药卫生—内科学]