3．OT和1．5T MRI定量心肌铁沉积的体外水模对比研究  

The study of quantitative myocardial iron deposition in water phantoms at 3.0T in comparison with 1.5T MRI

作　　者：彭鹏[1] 杨光鑫 张灵[1] 冯潇[1] 黄仲奎[1] 龙莉玲[1] 

机构地区：[1]广西医科大学第一附属医院放射科,广西南宁530021

出　　处：《实用放射学杂志》2017年第12期1951-1954,共4页Journal of Practical Radiology

基　　金：国家自然科学基金项目（81460260,81160175）.

摘　　要：目的 探讨3.0T MRI-T2＊定量不同浓度MnCl2水模的准确性、重复性及可行性。方法 制作不同浓度的MnCl2溶液水模，分别使用3.0T和1.5T MRI进行多回波GRE序列扫描并测量T2＊值和R2＊（1/ T2＊）值，行3.0T MRI重复扫描。使用Spearman相关分析探讨3.0T场强下R2＊值和T2＊值与不同浓度水模之间的关系；3.0T和1.5T场强下水模T2＊值之间的关系，并通过一元回归得到两者之间方程。用配对秩和检验和Bland-Altman法比较3.0T场强下2次测量的水模T2＊值的差异，计算组内相关系数（ICC）。结果 水模T2＊值与Mn浓度高度负相关（r=-1.000, P＜0.001），R2＊值与Mn浓度高度正相关（r=1.000, P＜0.001）。3.0T场强下测量的水模T2＊值与1.5T场强下的测量值呈高度正相关（r=1.000，P＜0.001），两者之间的回归方程为T2＊3.0T=0.651T2＊1.5T＋0.041。3.0T场强下2次测量的T2＊值无显著性差异（Z=-1.732，P=0.083），ICC为1.000。结论 3.0T MRI定量心肌铁沉积具有可行性。Objective To explore the feasibility, reproducibility and reliability of the T2 ＊ MRI technique in quantifying different concentrations of MnCl2 water phantoms at 3.0T. Methods The water phantoms with different concentrations of MnC12 underwent T2 ＊ imaging at both 1.ST and 3.0T MRI, and repeated imaging at 3.0T MRI after 1 month. A Spearman correlation was used to determine the relationship of T2 ＊ values and Mn concentrations, and established the linear regression equations by using the simple linear regression.Wilcoxon signed-rank sum test and Bland-Altman method were used to evaluate the reproducibility of twice T2 ＊ measurements at 3.0T, and the interclass correlation coefficient （ICC） was calculated. Results T2 ＊ values of the phantoms were negatively correlated to Mn concentrations （r=-1.000, P〈0.001）, and R2 ＊ values of the phantoms were positively correlated to Mn concentrations （r=l.000,P〈0.001）. T2 ＊ values of the phantoms measured at 3.0T were positively correlated to that measured at 1.5T （r= 1.000,P〈0.001 ）. The linear regression equation was T2 ＊ 3.0T =0.651T2 ＊ 1ST ＋0.041. There was no statistical difference of T2 ＊ values between the two measurements at 3.0T （Z=-1.732, P=0.083）, and ICC was 1.000. Conclusion 3.0T MRI is feasible to quantify cardiac iron deposition.

关 键 词：磁共振成像 铁 心脏 水模 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.11[医药卫生—诊断学]