启宫丸方对多囊卵巢综合征伴不孕症患者子宫动脉血流和内膜容受性的影响  

Effects of Qigong Pills Formula on Uterine Artery Blood Flow and Endometrial Receptivity of Patients with Polycystic Ovary Syndrome with Infertility

作　　者：张莲莲[1] 韩在刚[1] 杨锐[2] 

机构地区：[1]北华大学附属医院药学部,吉林吉林132000 [2]北华大学附属医院生殖医学中心,吉林吉林132000

出　　处：《中国药房》2017年第35期4967-4970,共4页China Pharmacy

摘　　要：目的:探讨启宫丸方辅助治疗对多囊卵巢综合征(PCOS)伴不孕症患者的子宫动脉血流和内膜容受性的影响。方法:选择2016年1-12月到我院就诊的86例PCOS伴不孕症患者,采用随机数字表法分为对照组和观察组,各43例。对照组患者采取化学药长方案垂体降调节治疗;观察组患者在对照组基础上给予启宫丸方辅助治疗,每日1剂,以水煎成400 m L,分早晚2次温服,用药至行人工受精术停止。比较两组患者治疗前和治疗后3个月的子宫超声指标和子宫内膜容受性,记录患者排卵、受孕以及不良反应发生情况。结果:治疗前,两组患者的子宫超声指标和内膜容受性指标比较,差异均无统计学意义(P>0.05)。治疗后3个月,两组患者的子宫内膜厚度明显增大,子宫内膜螺旋动脉搏动指数和阻力指数明显减小,整合素αvβ_3和葡萄糖转运体4(GLUT4)的阳性表达水平明显升高,且观察组均明显优于对照组,差异均有统计学意义(P<0.05);观察组患者的排卵率为83.72%,明显高于对照组的62.79%,差异有统计学意义(P<0.05);两组患者受孕率比较(27.91%vs.18.60%),差异无统计学意义(P>0.05)。两组患者均未见明显的不良反应发生。结论:启宫丸方辅助治疗有助于调节PCOS伴不孕症患者的子宫动脉血流动力学参数,增强子宫内膜容受性,从而提高排卵率。OBJECTIVE： To investigate the effects of Qigong pills formula on uterine artery blood flow and endometrial receptivity of patients with polycystic ovary syndrome （PCOS） with infertility. METHODS： A total of 86 PCOS patients with infertility in our hospital during Jan.-Dec. 2016 were divided into control group and observation group according to random number table, with 43 cases in each group. Control group was given western medicine pituitary down-regulation therapy. Observation group was additionally given adjuvant therapy of Qigong pills formula, a dose per day, decocted with water to 400 mL, morning and night until artificial fertilization stopped, on the basis of control group. The uterus ultrasonic indexes and endometrial receptivity were compared between 2 groups before treatment and 3 months after treatment. The occurrence of ovulation, pregnancy and ADR was recorded. RESULTS： Before treatment, there was no statistical significance in uterus ultrasonic indexes and endometrial receptivity indexes between 2 groups （P〉0.05）. Three months after treatment, endometrial thickness of 2 groups were increased significantly, while endometrial spiral arterial pulsatility indexes and resistance indexes were decreased significantly; the levels of αvβ3 and GLUT4 were increased significantly; observation group was significantly better than control group, with statistical significance （P〈0.05）. The ovulation rate of observation group was 83.72%, which was significantly higher than 62.79% of control group, with statistical significance （P〈0.05）. There was no statistical significance in pregnancy rate （27.91% vs. 18.60% ）between 2 groups （P〉0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： The adjuvant therapy of Qigong pills formula help to regulate the pa- rameters of uterine artery blood flow in PCOS patients with infertility, and strengthen endometrial receptivity so as to increase ovu- lation rate.

关 键 词：启宫丸方 多囊卵巢综合征 不孕症 子宫动脉 子宫内膜容受性 

分 类 号：R711.75[医药卫生—妇产科学] R271.14[医药卫生—临床医学]