常规剂量替罗非班联合半剂量瑞替普酶在ST段抬高性急性心肌梗死治疗中的临床效果  

Clinical effect of conventional dose of tirofiban combined with half dose of reteplase in the treatment of ST-segment elevation acute myocardial infarction

作　　者：段鸿建 

机构地区：[1]陕西省康复医院急诊科,陕西西安710065

出　　处：《临床医学研究与实践》2017年第34期18-19,共2页Clinical Research and Practice

摘　　要：目的探究常规剂量的替罗非班与半剂量瑞替普酶联合治疗ST段抬高性急性心肌梗死的临床效果。方法选取在我院就诊的ST段抬高性急性心肌梗死患者96例为研究对象,根据治疗方法不同分为观察组和对照组,每组48例。对照组患者给予常规剂量瑞替普酶治疗,观察组患者给予常规剂量替罗非班联合半剂量瑞替普酶治疗。比较两组患者的血管再通率、并发症发生率、神经功能缺损程度。结果观察组患者溶栓治疗30、60、120 min时的血管再通率均明显高于对照组,且随着溶栓治疗时间的延长,两组患者的血管再通率均明显提高(P<0.05);观察组患者的并发症总发生率(10.42%)略低于对照组的(12.49%)(P>0.05);治疗2 h时,两组患者NIHSS评分均显著降低,且观察组明显低于对照组(P<0.05)。结论对ST段抬高性急性心肌梗死患者应用常规剂量替罗非班联合半剂量的瑞替普酶治疗效果确切,有助于促进血管再通,值得推广应用。Objective To investigate the clinical effect and safety of conventional dose of tirofiban combined with half dose of remifetil in the treatment of ST-segment elevation acute myocardial infarction. Methods A total of 96 patients with ST-segment elevation acute myocardial infarction admitted in our hospital were selected and divided into treatment group and control group according to the different treatment methods, with 48 cases in each group. The control group was given conventional dose reteplase, and the observation group was treated with conventional dose of tirofiban combined with half dose of reteplase. The recanalization rate, incidence of complications and neurological deficit degree were compared between the two groups. Results The recanalization rates in the observation group were significantly higher than those in the control group at 30, 60 and 120 min after treatment, and as the extension of thrombolysis treatment time, the recanalization rates in the two groups significantly improved（P〈0.05）. The total incidence rate of complications in the observation group was 10.42%, which was slightly lower than 12.49% in the control group（P〉0.05）. At 2 h after the treatment, the NIHSS scores in the two groups significantly decreased, and that in the observation group was lower than the control group（P〈0.05）. Conclusion The conventional dose of tirofiban combined with half dose of reteplase is effective in patients with ST-segment elevation acute myocardial infarction, it is conducive to revascularization, which worthy of promotion and application.

关 键 词：替罗非班 瑞替普酶 ST段抬高性急性心肌梗死 

分 类 号：R542.2[医药卫生—心血管疾病]