分泌型卷曲相关蛋白5和N末端B型利钠肽原与慢性心力衰竭的相关性研究  

Correlative analysis between changes of secreted frizzled-related protein 5 and N-terminal B-type natriuretic peptide in patients with chronic heart failure

作　　者：金鑫[1] 郭炳彦[1] 李拥军 

机构地区：[1]河北医科大学第二医院心血管内四科,河北石家庄050000

出　　处：《河北医科大学学报》2017年第12期1365-1368,1372,共5页Journal of Hebei Medical University

基　　金：国家自然科学基金(81570345)

摘　　要：目的探讨分泌型卷曲相关蛋白5(secreted frizzled-related protein 5,sFRP5)和N末端B型利钠肽原(N-terminal B-type natriuretic peptide,NT-ProBNP)与慢性心力衰竭的相关性。方法将103例慢性心力衰竭患者按照美国纽约心脏病学会(New York Heart Association,NYHA)心功能分级分为NYHAⅡ、Ⅲ、Ⅳ级3组,选取同期进行健康体检的正常者44例为对照组。于清晨空腹抽血测定sFRP5、NT-ProBNP、空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白胆固醇,测量血压、身高、体质量,计算体质量指数,行心脏彩色超声检查,测量左心室舒张末期内径(left ventricular end-diastolic dimension,LVEDD)、左心室射血分数(left ventricular ejection fraction,LVEF)。结果与对照组相比,心力衰竭组sFRP5及NT-ProBNP水平均明显升高;随着心功能分级逐级递增,sFRP5、NTProBNP及LVEDD逐渐升高,LVEF水平逐渐下降(P<0.05);sFRP5、NT-ProBNP水平分别与心功能分级和LVEDD呈正相关,而与LVEF呈负相关(P<0.05)。结论 sFRP5和NT-ProBNP与慢性心力衰竭严重程度相关,二者对心力衰竭患者的早期诊断有重要意义。Objective To explore the correlation of serum levels of secreted frizzled-related protein 5(sFRP5)and N-terminal B-type natriuretic peptide(NT-ProBNP)with chronic heart failure(CHF).Methods One hundred and three CHF patients with New York Heart Association(NYHA)grade Ⅱ-Ⅳ and 44 healthy controls treated were summarized.The sFRP5,NTProBNP,fasting blood glucose,total cholesterol,triacylglycerol,low density lipoprotein cholesterol were detected,the height,weight,body mass index,blood pressure were taken and left ventricular ejection fraction(LVEF)and left ventricular end-diastolic dimension(LVEDD)were measured by echocardiography.Results The levels of sFRP5 and NT-proBNP were significantly increased compared with the control group,the levels of sFRP5,NT-proBNP and LVEDD were gradually increased whereas the LVEF was decreased with NYHA classification(P<0.05).sFRP5 and NT-proBNP levels were positively correlated with NYHA grade and LVEDD respectively,and negatively correlated with LVEF(P<0.05).Conclusion sFRP5 and NT-proBNP are associated with the severity of cardiac function,and the combined application of them could be effective indexes for evaluating early diagnosis of chronic heart failure.

关 键 词：心力衰竭 利钠肽 脑 分泌型卷曲相关蛋白5 

分 类 号：R541.6[医药卫生—心血管疾病]