幼年巴马小型猪背景数据的建立和结果分析  

Acquisition and Analysis of Basic Data of Juvenile Bama Miniature Pigs

作　　者：郭新苗 王莹 孟骅 余洋 周亮 王灿 范潇予 靳洪涛 魏金锋[1,2] 

机构地区：[1]北京协和建昊医药技术开发有限责任公司,北京100176 [2]中国医学科学院药物研究所新药安全评价研究中心,北京100050

出　　处：《中国药物警戒》2017年第11期646-652,共7页Chinese Journal of Pharmacovigilance

基　　金：重大新药创制专项支持基金(2013ZX09302302):医科院国际标准药物安全性评价技术平台建设;(2012ZX09301002-001-009):药物安全性评价

摘　　要：目的建立不同日龄幼年巴马小型猪体重、体长、体温、心电指标、血液学指标、血液生化指标、凝血指标、免疫学指标、尿液学指标、胫骨长度、脏器重量、脏器系数等参数的背景数据。方法 30只幼年巴马小型猪(15雌,15雄),对其进行正常饲养管理,36日龄和64日龄分别剖杀18只(9雌,9雄)和12只(6雌,6雄)。检查指标为,8日龄~64日龄体重、体长、体温,7日龄、35日龄、63日龄心电图,36日龄和64日龄血液学指标、血液生化指标、凝血指标、T细胞亚群、胫骨长度、部分脏器脏器重量和脏器系数,使用SPSS统计软件计算各项指标均值和标准差。结果及结论初步建立了不同日龄巴马小型猪各项生理指标的背景数据库,为幼年巴马小型猪在非临床安全性评价的应用提供参考。Objective To acquire and analyze the basic data of different day old juvenile Bama miniature pigs, the data mainly include body weight, body length, body temperature, electrocardiograph data, hematological index, blood biochemical indexes, blood coagulation indexes, immunological indexes, urine indexes, tibia length, organ weight and organ coefficient. Methods The 30 juvenile Bama miniature pigs（15 females and 15 males） were fed and managed normally in this experiment. The body weight, body length, body temperature were measured between 8~64 days old every 7 days. The electrocardiograph data were collected at 7, 35, 63 days old. The hematological index, blood biochemical indexes, blood coagulation indexes, T cell subsets and tibia length were measured at 36, 64 days old. 18 Bama miniature pigs（9 females and 9 males） were killed at 36 days old and the other 12 Bama miniature pigs（6 females and 6 males） were killed at 64 days old to measure the organ weight and organ coefficient. The mean value and standard deviation were calculated using SPSS software. Results and Conclusion The research established the basic data of physiological indexes of juvenile Bama miniature pigs at different days old, these data may be helpful to the research of juvenile Bama miniature pigs.

关 键 词：幼年巴马小型猪 实验动物 背景数据 

分 类 号：R965[医药卫生—药理学]