血清胶原相关指标、肝功能指标及网织红细胞参数对肝硬化患者的诊断价值研究  

Study on the diagnostic value of related serum collagen indexes,liver function indexes and reticulocyte parameters in patients with cirrhosis

作　　者：荣爱国 

机构地区：[1]山西省中西医结合医院检验科,太原030013

出　　处：《国际检验医学杂志》2017年第23期3222-3224,3227,共4页International Journal of Laboratory Medicine

摘　　要：目的观察与研究血清胶原相关指标、肝功检测指标及网织红细胞参数在肝硬化患者诊疗过程中的检测价值。方法将2015年2月至2016年5月于该院接受治疗的54例肝硬化患者设为观察组,将54例同期体检健康者设为对照组,检测并比较两组血清胶原相关指标、肝功能检测指标及网织红细胞参数,统计并比较不同Child-Pugh分级、不同分类肝硬化患者的胶原相关指标、肝功能检测指标及网织红细胞参数。结果观察组的血清胶原相关指标Ⅲ型前胶原(PⅢP)、Ⅰ型前胶原羧基端原肽(PⅠCP)及Ⅳ型胶原(CⅣ)分别为(10.25±0.95)ng/L、(145.87±16.34)μg/L及(85.95±7.93)μg/L;肝功能检测指标天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)及谷氨酰胺转移酶(GGT)分别为(32.52±4.15)U/L、(33.23±3.56)U/L及(26.86±2.53)U/L;网织红细胞参数网织红细胞计数(RET)、未成熟红细胞指数(IRF)及网织红细胞生成指数(RPI)分别为(1.72±0.17)%、(20.87±2.23)%及(1.79±0.20),均高于对照组相应指标(1.08±0.11)%、(14.87±1.56)%和(0.81±0.18)%,差异有统计学意义(P<0.05)。不同Child-Pugh分级肝硬化患者的胶原相关指标、肝功检测指标及网织红细胞参数存在差异,且差异有统计学意义(P<0.05)。不同分类肝硬化患者的检测结果差异无统计学意义(P>0.05)。结论血清胶原相关指标、肝功指标及网织红细胞参数对于肝硬化患者的临床诊断价值较高。Objective To observe and study the diagnostic value of related serum collagen indexes Jiver function indexes and reticulocyte parameters in patients with cirrhosis. Methods 54 patients with cirrhosis in our hospital from February 2015 to May 2016 were selected as the observation group, 54 healthy persons at the same time were selected as the control group, and then the related serum collagen indexes,liver function and reticulocyte parameters of two groups were detected and compared. The serum collagen related indexes, liver function indexes and reticulocyte parameters of observation group with different Child-Pugh classifica-tions and different types of cirrhosis were analyzed and compared. Results The related serum collagen indexes including PIH P ,P I CP and C]V of observation group were（ 10. 25 ± 0. 95） ng/L ,（145. 87± 16. 34） jug/L and（85. 95 ± 7. 93） jug/L respectively, the liver function indexes including AST,ALT and GGT were（32. 52 ± 4. 15）U/L ,（33.23 ±3. 56）U/L and（26. 86± 2. 53）U /L respectively,and the reticulocyte parameters including RE T ,IRF and RPI were（1 .72± 0.17） % , （20. 87± 2. 23） % and（l . 79 ±0. 20）respectively,and they were all higher than those of control group. The related serum collagen indexes, liver function and reticulocyte parameters of observation group with different Child-Pugh classifications of cirrhosis had significant differences（P 〈0. 05） , while the detection results of observation group with different types of cirrhosis had no significant differences（P 〉0. 05）. Conclusion The related serum collagen indexes, liver function indexes and reticulocyte parameters have a relatively high diagnostic value for the pa-tients with cirrhosis.

关 键 词：血清 胶原相关指标 肝功指标 网织红细胞参数 肝硬化 

分 类 号：R446.1[医药卫生—诊断学] R575.2[医药卫生—临床医学]