头孢克肟治疗急性细菌性肠炎患者临床效果及对血清炎症因子的影响研究  

Clinical effect of Cefixime on the treatment for patients with acute bacterial enteritis and the influence on serum inflammatory factors

作　　者：姜云达[1] 岳德永[1] 顾立华 杨忠英[1] 

机构地区：[1]上海交通大学医学院附属新华医院崇明分院药剂科,上海202150 [2]上海交通大学医学院附属新华医院崇明分院急危重症科,上海202150

出　　处：《国际检验医学杂志》2017年第23期3225-3227,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨头孢克肟治疗急性细菌性肠炎患者临床效果及对血清炎症因子的影响。方法选取2015年6月至2016年9月该院收治的92例急性细菌性肠炎患者作为研究对象,采用随机数字表法分为头孢克肟组、头孢克洛组,每组各46例,两组分别给予头孢克肟、头孢克洛治疗,连续治疗5~7d,观察临床治疗效果。结果治疗后1~3d,头孢克肟组患者的腹泻次数低于头孢克洛组,差异具有统计学意义(P<0.05);治疗3天后,头孢克肟组患者的急性反应蛋白(CRP)、铜蓝蛋白(CER)、α1-酸性糖蛋白(AAG)、白介素-8(IL-8)、降钙素原(PCT)、肿瘤坏死因子(TNF-α)的水平均低于头孢克洛组,差异具有统计学意义(P<0.05);治疗3d后,头孢克肟组患者的显效率为50.00%、有效率为47.83%、无效率为2.17%;头孢克洛组显效率为32.61%、有效率为56.52%、无效率为10.87%,头孢克肟组治疗效果优于头孢克洛组,差异具有统计学意义(P<0.05)。结论头孢克肟治疗急性细菌性肠炎患者的临床效果优于头孢克洛。Objective To investigate the clinical effect of cefixime on the treatment for patients with acute bacterial enteritis and the influence on serum inflammatory factors. Methods A total of 92 cases with acute bacterial enteritis, treated in our hospital from June 2015 to September 2016, were selected as the research object, and randomly divided into cefixime group and cefaclor group, with 46 cases in each group. The cefixime group was given treatment of cefixime,and cefaclor group was given treatment of cefa-clor, for 5 to 7 consecutive days. Observation of clinical treatment effect was performed. Results On the first three days after treat-ment, the number of diarrhea of cefixime group is lower than the one of cefaclor group,and the difference was statistically significant （P 〈0. 05） ;after Day 3 of treatment, the levels of CRP ,C E R , A A G , IL-8 ,PC T ,TNF-alpha of cefixime group were lower than those of cefaclor group,and the difference was statistically significant （P 〈0. 05） ; after Day 3 of treatment, efficiency rate, effective rate and invalid rate of cefixime group were 50. 0%,47. 83 % and 2. 17% , respectively; efficiency rate, effective rate and invalid rate of cefaclor group were 32. 61% ,56. 52% and 10. 87% respectively; the treatment effect of cefixime group is better than that of cefaclor group,and the difference was statistically significant （P 〈0. 05）. Conclusion The clinical effects of cefixime on the treatment for patients with acute bacterial enteritis is better than that of cefaclor.

关 键 词：头孢克肟 急性细菌性肠炎 炎症因子 

分 类 号：R516.1[医药卫生—内科学]