1,5-二芳基-3-苯甲酰氧基吡唑类化合物的合成及生物活性  

Synthesis and Biological Activities of 1,5-Diaryl-1H-pyrazol-3-yl Benzoates

作　　者：贾红圣[1] 

机构地区：[1]苏州健雄职业技术学院医药科技学院,江苏太仓215411

出　　处：《农药》2017年第12期871-874,共4页Agrochemicals

基　　金：苏州市生物医药绿色合成重点实验室项目(SZSD201402)

摘　　要：[目的]寻找具有较好生物活性的活性分子。[方法]在苯甲酰氯的骨架中引入具有良好生物活性的1,5-二芳基-1H-3-羟基吡唑化合物,设计合成一系列1,5-二芳基-3-苯甲酰氧基吡唑化合物,并进行目标化合物生物活性测试。[结果]所合成目标化合物结构经IR、1H NMR、MS和元素分析确证。生物活性测试结果表明:部分目标化合物对小菜蛾和朱砂叶螨有良好的生物活性。[结论]1,5-二芳基-3-苯甲酰氧基吡唑类化合物具有较好的生物活性,在其结构基础上进行进一步的结构修饰,期望得到具有较高抗病毒活性的有机活性分子。[Aims] This paper aims to explore active molecules with potent biological activities. [Methods] A series of1,5-diaryl-1 H-pyrazol-3-yl benzoates were synthesized via the method of combing the 1,5-diaryl-3-hydro-xypyrazoles group into the structure of benzoyl chloride, their bioassay activities were evaluated. [Results] The title compounds were confirmed by IR,1 H NMR, MS and elemental analysis, and the results of biological assay indicated that some compounds showed good biological activities against diamondback moth and Tetranychus cinnabarinus.[Conclusions] 1,5-Diaryl-1 H-pyrazol-3-yl benzoates exhibited good bioassay activities and some small organic molecules with potent biological activities might be obtained via the structural modification based on the structure of1,5-diaryl-1 H-pyrazol-3-yl benzoates.

关 键 词：1 5-二芳基-3-苯甲酰氧基吡唑 合成 生物活性 

分 类 号：TQ450.1[化学工程—农药化工]