茵黄清木合剂治疗肝胆湿热型免疫耐受期乙型肝炎病毒携带者的临床观察  

Clinical observation of Yinhuang-muqing mixture on hepatitis B virus carrier with liver and gallbladder damp-heat type in immune tolerant phase

作　　者：付亚 李桂珍[2] 

机构地区：[1]湖北中医药大学 [2]湖北省武汉市第一医院消化内科,湖北武汉430022

出　　处：《河北中医》2017年第11期1637-1640,1645,共5页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察茵黄清木合剂对肝胆湿热型免疫耐受期乙型肝炎病毒(HBV)携带者的治疗效果,并评价其疗效。方法将120例HBV携带者随机分为2组。治疗组60例,给予茵黄清木合剂治疗;对照组60例,不使用任何药物治疗,定期随访,监测患者肝功能、HBV载量及标志物水平变化等。2组均观察治疗3个月,停药后再连续观察3个月。分别观察2组治疗3个月后及停药3个月后的疗效变化情况,并比较2组治疗前、治疗3个月后及停药3个月后HBV-DNA水平及HBV e抗原(HBeAg)转阴变化情况。结果治疗后3个月后,治疗组总有效率90.0%,对照组总有效率66.7%,停药3个月后治疗组总有效率91.7%,对照组总有效率65.0%,治疗组治疗3个月后及停药3个月后总有效率均高于对照组(P<0.05);对照组治疗3个月后及停药3个月后HBV-DNA水平与本组治疗前比较无明显变化(P>0.05),治疗组治疗3个月后及停药3个月后HBV-DNA水平与本组治疗前比较均有明显降低(P<0.05),且低于对照组同期HBV-DNA水平(P<0.05);治疗3个月后治疗组HBeAg转阴2例,对照组转阴1例,停药3个月后治疗组HBeAg转阴3例,对照组转阴1例,2组治疗3个月后及停药3个月后HBeAg转阴情况比较差异均无统计学意义(P>0.05)。结论茵黄清木合剂治疗肝胆湿热型免疫耐受期HBV疗效确切,可明显改善患者临床症状、体征,提高临床疗效,降低HBV-DNA水平,降低病毒复制,安全可靠,具有明显的优势。Objective To observe the clinical effects of Yinhuang-muqing mixture on hepatitis B virus( HBV) carrier with liver and gallbladder damp-heat type in immune tolerant phase,and evaluate its efficacy.Methods 120 HBV carriers were randomly divided into two groups. 60 cases in the treatment group were treated by Yinhuang-muqing mixture. And 60 cases in the control group without any drug treatment,regular follow-up,and liver function,HBV load and the changes of marker level were monitored. 2 groups were observed and treated for 3 months,then continue observed for 3 months after drug withdrawal. The changes of curative effect after treatment 3 months and after drug withdrawal 3 months were observed respectively in two groups. The changes of HBV-DNA levels and Hepatitis Be Antigen( HBeAg) negative were compared before and after treatment 3 months and after 3 months drug withdrawal in two groups. Results After treatment 3 months,the total effective rate was 90. 0% in the treatment group,and 66. 7% in the control group. The total effective rate was 91. 7% in the control group and65. 0% in the control group after drug withdrawal 3 months. The total effective rates after treatment 3 months and after drug withdrawal 3 months in the treatment group were higher than that in the control group( P < 0. 05). There was no statistical difference on the level of HBV-DNA between before and after treatment 3 months,between before and after drug withdrawal 3 months in the control group( P > 0. 05). The levels of HBV-DNA after treatment 3 months and after drug withdrawal 3 months were reduced in the treatment group( P < 0. 05),and which in the treatment group was lower than that in the control group at the same period( P < 0. 05). After treatment 3 months,2 cases of HBeAg were turning negative in treatment group,and 1 case of HBeAg was turning negative in control group. After drug withdrawal 3 months,3 cases of HBeAg were turning negative in treatment group,and 1 case of HBeAg was turning negative in control group. There was no statistica

关 键 词：肝炎 乙型 肝胆湿热 中药疗法 

分 类 号：R289.61[医药卫生—方剂学]