热毒宁注射液联合吸入用乙酰半胱氨酸溶液治疗小儿毛细支气管炎疗效观察  

Clinical observation of reduning injection combined with inhaled acetylcysteine solution on child bronchiolitis

作　　者：陈雪丽[1] 杨磊[1] 

机构地区：[1]湖北省妇幼保健院儿科呼吸科,湖北武汉430070

出　　处：《河北中医》2017年第11期1672-1676,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：湖北省卫生和计划生育委员会2015-2016年度科研立项项目(编号:WJ2015MB122)

摘　　要：目的观察热毒宁注射液联合吸入用乙酰半胱氨酸溶液治疗小儿毛细支气管炎的疗效。方法将60例年龄为6个月~1岁的毛细支气管炎患儿随机分为3组,每组各20例,其中治疗期间5例(治疗组1例、对照1组2例、对照2组2例)剔除。对照组1组18例进行常规治疗,对照2组在对照1组治疗的基础上加吸入用乙酰半胱氨酸溶液雾化吸入,治疗组19例在对照2组治疗的基础上加热毒宁注射液静脉滴注。比较3组患儿主要症状、体征(包括咳嗽、咳憋、喘息、肺部湿啰音)消失时间及住院时间、临床疗效。结果 3组间咳嗽、喘息、肺部湿啰音消失时间比较差异无统计学意义(P>0.05);治疗组咳憋消失时间早于对照1组及对照2组(P<0.05),对照2组与对照1组比较差异无统计学意义(P>0.05);治疗组住院时间短于对照1组(P<0.05),但治疗组与对照2组、对照2组与对照1组之间比较差异无统计学意义(P>0.05)。治疗组总有效率优于对照1组(P<0.05),但治疗组与对照2组、对照2组与对照1组间总有效率比较差异无统计学意义(P>0.05)。结论热毒宁注射液静脉滴注联合吸入用乙酰半胱氨酸溶液雾化吸入治疗小儿毛细支气管炎能更快地缓解咳憋症状,缩短住院时间,疗效佳。Objective To observe the clinical effects of reduning injection combined with inhaled acetylcysteine solution on the treatment of child bronchiolitis. Methods Sixty children with bronchiolitis of 6 to 12 months were randomly divided into three groups,20 cases in each group,5 cases were removed during treatment,which including one case in treatment group,two cases in control group 1 and 2 cases in control group 2. 18 cases in the control group 1 were treated by conventional treatment. The control group 2 was treated by inhaled acetylcysteine solution on the basis of the control group 1. 19 cases in the treatment group were treated by reduning injection on the basis of the control group 2. The disappearance time of main symptoms and signs including cough,cough suppress,wheezing,lung moist rales,hospital stay and clinical curative effects were compared in the three groups. Results There was no statistical difference on the disappearance time of cough,wheezing and lung moist rales among the three groups( P > 0. 05). The disappearance time of cough suppress in the treatment group was earlier than that in the control group 1 and control group 2( P < 0. 05),and there was no statistical difference on that between the control group1 and control group 2( P > 0. 05). The hospital stay in the treatment group was shorter than that in the control group1( P < 0. 05),and there was no statistical difference on that between the treatment group and control group 2,control group 2 and control group 1( P > 0. 05). The total effective rate in the treatment group was superior to that in the control groups 1( P < 0. 05), and there was no statistical difference on that between the treatment group and control group 2,control group 2 and control group 1( P > 0. 05).Conclusion Reduning injection combined with inhaled acetylcysteine solution can relieve the symptom of cough suppress faster,shorten the hospital stay with good effect on the treatment of child bronchiolitis.

关 键 词：细支气管炎 儿科学 中西医结合疗法 中成药 注射剂 定量雾化吸入器 

分 类 号：R725.622.058[医药卫生—儿科] R283.61[医药卫生—临床医学]