机构地区:[1]北京结核病胸部肿瘤研究所中心办公室,101149 [2]首都医科大学附属北京胸科医院中心办公室感染管理处 [3]首都医科大学附属北京胸科医院院长办公室 [4]内蒙古医科大学公共卫生学院 [5]广州市胸科医院 [6]上海市疾病预防控制中心防治科 [7]天津市结核病控制中心防治科 [8]河南省疾病预防控制中心防治科 [9]河北省疾病预防控制中心防治科 [10]广西壮族自治区疾病预防控制中心防治科 [11]重庆市结核病防治所防治科 [12]云南省疾病预舫控制中心防治科
出 处:《结核病与胸部肿瘤》2017年第3期184-189,共6页Tuberculosis and Thoracic Tumor
摘 要:目的探讨涂阳肺结核患者并发糖尿病的影响因素,为制定肺结核并发糖尿病相关策略提供参考依据。方法选取2008年10月至2010年12月期间上海市、广东省、天津市、河北省、河南省、重庆市、广西壮族自治区及云南省等8个地区共49个实施单位确诊的1879例涂阳肺结核患者作为研究对象。采用前瞻性研究方法,通过统一设计的调查问卷,问卷的效度和信度分别为9.62及0.89,共发出调查问卷2142份,回收有效问卷1879份,收集患者基本特征、吸烟、饮酒及治疗类型信息,分析肺结核并发糖尿病的危险因素。结果在1879例患者叶1,单纯性肺结核患者1696例,占90.26%(1696/1879),肺结核并发糖尿病者183例,占9.74%(183/1879)。男性、45-64岁、65岁及以上、体质量指数〈18.5及就职于企事业单位者在单纯肺结核组中分别占70-81%(1201/1696)、27.48%(466/1696)、10.55%(179/1696)、39.50%(670/1696)、5.90%(100/1696);肺结核并发糖尿病组中分别占82.51%(151/183)、61.75%(113/183)、16.94%(31/183)、21.86%(40/183)、8.74%(16/183)。多因素非条件logistic分析结果表明,男性(对比女性)、45~64岁(对比≤24岁者)、65岁及以上(对比≤24岁者)、BM[〈18.5(对比BMI为18.5~24.0者)及就职于企事业单位(对比农民及外来务工者)是肺结核并发糖尿病的危险因素,OR(95%CI)值分别为1.56(1.01~2.41)、27.45(7.44~101.22)、18.23(7.21~94.47)、2.24(1.34~3.75)及2.91(1.49~5.67)。结论男性、中老年、体质量低及就职于企事业单位的涂阳肺结核患者更易并发糖尿病。Objective To expiore the risk factors of smear-positive pulmonary tuberculosis(PTB)patients with diabetes mellitus(DM), to provide the evidence for generating prevention and treatment strategy of PTB with DM. Methods A prospective study was conducted in forty nine units from eight provinces between October 2008 and December 2010. A unified questionnaire were collected from 1879 smear positive PTB in order to obtain demographic characteristics, smoking, drinking and treatment history of, to explore risk factors of PTB with DM The validity and reliability of questionnaire was 9.62 and 0.89 respectively. Results Of 1879 PTB patients, 9.74% (183/1879) had DM and 90.26% (1696/1879) had not DM. There were 70.81% (1201/1696), 27.48% (466/1696), 10.55% (179/1696), 39.50% (670/1696), and 5.90% (100/1696) of patients belonged to male, 45-64 years. 65 years and higher, body mass index (BMI)〈18.5 kg/m2 and employee from enterprise or public institution groups, respecitively. Among PTB with DM patients group were 82.51% (151/183), 61.75% (113/183), 16.94% (31/183), 21.86% (40/183), and 8.74% (16/183) respectively. Multivariate logistic regression analysis revealed that male, 45-64 age group, 66 age and higher group, BMI〈18.5 kg/m2, employee were significantly associated with the occurrence of smear-positive PTB with DM, the OR (95% CI) of which were 1.56 (1.01-2.41), 27.45 (7.44-101.22), 18.23 (7.21-94.47), 2.24 (1.34- 3.75) and 2.91 (1.49-5.67), respectively. Conclusion The smear positive PTB from male, middle-aged and old-aged groups, BMI〈18.5 kg/m2, and employee from enterprise or public institution groups increased the risk of DM.
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