基于数据挖掘的藏医药治疗高原红细胞增多症方剂组方用药规律分析  

Analysis of Tibetan Medicine Treatment of Hapc Prescription and Medication Rules Based on Data Mining

作　　者：更藏加[1,2] 尕藏措 张鹰 郭伟晨 德洛[1] 泽翁拥忠[1] 张丹[1] 聂佳[1] 刚焕晨雷 

机构地区：[1]成都中医药大学民族医药学院,四川成都611137 [2]青海大学藏医学院,青海西宁810016 [3]青海省藏医院,青海西宁810007

出　　处：《辽宁中医杂志》2017年第11期2274-2277,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81603394;81503362);国家社会科学基金项目(16XMZ065;12XMZ074);四川省青年基金项目(16XJC850001);四川省教育厅省属高校科研创新团队建设计划(11TD004);青海大学医学院中青年科学基金项目(2016-KY-8);青海大学二类课程建设项目(KCFL-15-3-4)

摘　　要：目的:基于数据挖掘方法,运用中医传承辅助平台软件(V2.5),分析《四部医典》等藏医药书籍中治疗HAPC方剂的组方用药规律,为进一步挖掘藏医治疗HAPC方案及新药的研发提供参考。方法:HAPC属于藏医血隆病的范畴,俗称"多血症"。为揭示藏医药治疗该病方剂组方用药规律,通过整理《四部医典》等藏医药书籍中的相关治疗方剂,应用中医传承辅助平台软件(V2.5),构建藏医治疗HAPC的方剂数据库,采用软件集成的数据挖掘方法,进行频次统计、组方规律、关联规则分析、新方分析和证型分布。结果:收集了治疗HAPC的210首方剂,确定了处方中药物出现的频次、常用药对及组合,其中使用频率最高的10味药分别是诃子、木香、红花、余甘子、肉豆蔻、豆蔻、丁香、土木香、天竺黄、毛诃子,累计用药频率达33.19%。发现支持度≥20%,置信度≥0.9的关联规则共演化得出新处方11首。结论:用药频率较高藏药的药性均以针对血型HAPC治疗为主,依次是隆型、赤巴型、培根型、木布病等5种分型,体现了该病在不同分型下有不同的治疗原则和组方用药规律,为藏医临床辨证论治和进一步新药开发提供了科学意义及数据支撑。Objective： Applying TCM inheritance auxiliary platform software V2. 5 to analyze the law of prescription drug HAPC in the treatment of Sibu Yidian and other books in Tibetan medicine for providing a reference for further mining HAPC therapy and drug development in Tibetan medicine based on the method of data mining. Methods： HAPC belongs to the category of Tibetan blood lung disease,commonly known as Plethora. In order to reveal the Tibetan medicine treatment of the prescription drug law in this disease,we can arrange Sibu Yidian,etc. Tibetan medicine books in treatment of HAPC applicate the TCM inheritance auxiliary platform software V2. 5 to construct the Tibetan medicine treatment prescription database of HAPC. By using the data mining method of software integration we analyzed the frequency statistics,prescription law,association rules,new prescription analysis and syndrome distribution. Results： We collected 210 prescriptions for treatment of HAPC and determined the frequency of prescription drugs,commonly used in combination,myrobalan,woody,saffron,cardamom,clove,nutmeg,emblica,elecampane,Tianzhuhuang and Maohezi which were the most frequently used 10 herbs（ cumulative frequency of medication up to 33. 19%）.It is found that supporting degree 〉20,confidence 〉0. 9 association rules can lead to 11 new prescriptions. Conclusion： The higher frequency of drug use was mainly based on the treatment of blood type HAPC. The resistance of medication frequency higher drugs are mainly aimed at the treatment of blood type HAPC,followed by the Long type,Chi Ba type,Bacon type and Mu Bu. It shows that the disease has different treatment principles,prescription and medication rules in different types meanwhile provides high guiding significance and data support for Tibetan clinical syndrome differentiation and treatment and further development of new drugs.

关 键 词：藏医药 HAPC 中医传承辅助平台 方剂 组方用药规律 

分 类 号：R291.4[医药卫生—民族医学]