紫斑谷螟豹皮樟虫茶小鼠急性毒性和骨髓红细胞微核试验研究  

Acute Toxicity Test and Micronucleus Test of Pyralis Farinalis-Litsea Coreana Insect Tea in Mice

作　　者：王芳[1] 陈松 刘仁普 杨茂发[1] 

机构地区：[1]贵州大学昆虫研究所/贵州山地农业病虫害重点试验室,贵州贵阳550025

出　　处：《山地农业生物学报》2017年第5期58-61,共4页Journal of Mountain Agriculture and Biology

基　　金：国家自然科学基金项目"贵州主要虫茶昆虫生物学生态学及所产虫茶评价研究"(31260526)

摘　　要：用小鼠最大耐受量法、小鼠骨髓嗜多染红细胞微核试验和小鼠精子畸形试验等方法,究紫斑谷螟豹皮樟虫茶对小鼠的急性毒性和致突变性作用。结果显示,紫斑谷螟豹皮樟虫茶的小鼠急性经口LD50>30 g/kg·bw,小鼠骨髓红细胞微核试验结果为阴性。结果表明,紫斑谷螟豹皮樟虫茶属无毒物,对小鼠体细胞无致突变性。The acute toxicity and mutagenicity of Pyralis farinalis-Litsea coreana Insect Tea in mice were investigated. Acute toxicity test,bone marrow polychromatic erythrocyte micronucleus test in mice were adopted. The results showed that the acute oral maximum LD50 was higher than 30 g/kg·bw; the micronucleus test indicated that the difference between treating group and negative control group was not remarkable. The results proved that the Pyralis farinalis-Litsea coreana Insect Tea is belongs to practical actox-ic and could not cause mutagenesis.

关 键 词：急性毒性 微核试验 致突变作用 小鼠 

分 类 号：Q291[生物学—细胞生物学]